Molecular and cellular endocrinology · 2019
Galectin-3 plays an important role in endometriosis development and is a target to endometriosis treatment.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Mattos Rômulo Medina de, Machado Daniel Escorsim, Perini Jamila Alessandra, Alessandra-Perini Jéssica, Meireles da Costa Nathália de Oliveira, Wiecikowski Adalgisa Felippe da Rocha de Oliveira, Cabral Katia Maria Dos Santos, Takiya Christina Maeda, Carvalho Renato Sampaio, Nasciutti Luiz Eurico
Аннотация
This study aimed to analyze galectin-3 importance in endometriotic lesions development and the effect of recombinant Gal-3 carbohydrate recognition domain (Gal3C) in experimental endometriosis treatment. Experimental endometriosis was induced in WT and Gal-3-/- mice. Initially developed lesions were macroscopically and histologically analyzed, including immunohistochemical analysis. Then, WT mice were treated with Gal3C for 15 days. Gal-3 deficiency and Gal3C treatment significantly impaired endometriosis development. A significant decrease in lesions implantation and size, VEGF and VEGFR-2 expression, vascular density and macrophage distribution were observed in Gal-3 absence or inhibition. A greater presence of iNOS positive cells was observed in knockout mice lesions, while the presence of Arginase positive cells was higher in the WT animal lesions. In addition, COX-2 and TGFb1 were reduced by Gal3C treatment. Data showed here indicate a relevant role of Gal-3 in endometriosis development and highlight a target of endometriosis treatment using Gal-3 inhibitor.