Experimental and therapeutic medicine · 2017
Glucose-regulated protein 78 is an antiviral against hepatitis A virus replication.
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Jiang Xia, Kanda Tatsuo, Haga Yuki, Sasaki Reina, Nakamura Masato, Wu Shuang, Nakamoto Shingo, Shirasawa Hiroshi, Okamoto Hiroaki, Yokosuka Osamu
Аннотация
Infection with hepatitis A virus (HAV) is a major cause of acute hepatitis globally and it is important to identify the mechanisms of HAV replication. Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum (ER) chaperone and serves a role in unfolded protein response pathways. Previous studies have demonstrated that GRP78 functions as an endogenous antiviral factor. In the present study, two loss-of-function studies using GRP78 were completed to elucidate the role of GRP78 in HAV infection. HAV replication was observed to be enhanced by deficient GRP78 although GRP78-deficiency also led to lower expression of ER stress molecules downstream of GRP78. Therefore, GRP78 appears to be a potential novel defensive molecule against HAV in hepatocytes.