Low Dose Cyclophosphamide Therapy in Lichen Amyloidosis.

Nine patients (5 males and 4 females) with lichen amyloidosis were treated with 50 mg cyclophosphamide orally daily for 6 months to 1 year. Itching was decreased by 80 - 90% in all the 9 patients within 4 months, and 4 patients showed 50-75% improvement at the end of,6 months but subsequently there was no further improvement. In the other 3 patients, ,there 'was no change, in the papules during a follow - up of 6 months. The side effects possibly attributable to cyclophosphamide included a reversible leucopenia. (less than 4000-mm3) in one patient and transient diffuse alopecia in 3. 3.