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DOI 10.1038/ng.3704

Медицинская библиотека · Nature genetics · 2016

Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.

Stucki David, Brites Daniela, Jeljeli Leïla, Coscolla Mireia, Liu Qingyun, Trauner Andrej, Fenner Lukas, Rutaihwa Liliana, Borrell Sonia, Luo Tao, Gao Qian, Kato-Maeda Midori, Ballif Marie, Egger Matthias, Macedo Rita, Mardassi Helmi, Moreno Milagros, Tudo Vilanova Griselda, Fyfe Janet, Globan Maria, Thomas Jackson, Jamieson Frances, Guthrie Jennifer L, Asante-Poku Adwoa, Yeboah-Manu Dorothy, Wampande Eddie, Ssengooba Willy, Joloba Moses, Henry Boom W, Basu Indira, Bower James, Saraiva Margarida, Vaconcellos Sidra E G, Suffys Philip, Koch Anastasia, Wilkinson Robert, Gail-Bekker Linda, Malla Bijaya, Ley Serej D, Beck Hans-Peter, de Jong Bouke C, Toit Kadri, Sanchez-Padilla Elisabeth, Bonnet Maryline, Gil-Brusola Ana, Frank Matthias, Penlap Beng Veronique N, Eisenach Kathleen, Alani Issam, Wangui Ndung'u Perpetual, Revathi Gunturu, Gehre Florian, Akter Suriya, Ntoumi Francine, Stewart-Isherwood Lynsey, Ntinginya Nyanda E, Rachow Andrea, Hoelscher Michael, Cirillo Daniela Maria, Skenders Girts, Hoffner Sven, Bakonyte Daiva, Stakenas Petras, Diel Roland, Crudu Valeriu, Moldovan Olga, Al-Hajoj Sahal, Otero Larissa, Barletta Francesca, Jane Carter E, Diero Lameck, Supply Philip, Comas Iñaki, Niemann Stefan, Gagneux Sebastien

СтатьяПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАПеревод в очереди

Аннотация

Generalist and specialist species differ in the breadth of their ecological niches. Little is known about the niche width of obligate human pathogens. Here we analyzed a global collection of Mycobacterium tuberculosis lineage 4 clinical isolates, the most geographically widespread cause of human tuberculosis. We show that lineage 4 comprises globally distributed and geographically restricted sublineages, suggesting a distinction between generalists and specialists. Population genomic analyses showed that, whereas the majority of human T cell epitopes were conserved in all sublineages, the proportion of variable epitopes was higher in generalists. Our data further support a European origin for the most common generalist sublineage. Hence, the global success of lineage 4 reflects distinct strategies adopted by different sublineages and the influence of human migration.

Для цитирования: Stucki David, Brites Daniela, Jeljeli Leïla, Coscolla Mireia, Liu Qingyun, Trauner Andrej, Fenner Lukas, Rutaihwa Liliana, Borrell Sonia, Luo Tao, Gao Qian, Kato-Maeda Midori, Ballif Marie, Egger Matthias, Macedo Rita, Mardassi Helmi, Moreno Milagros, Tudo Vilanova Griselda, Fyfe Janet, Globan Maria, Thomas Jackson, Jamieson Frances, Guthrie Jennifer L, Asante-Poku Adwoa, Yeboah-Manu Dorothy, Wampande Eddie, Ssengooba Willy, Joloba Moses, Henry Boom W, Basu Indira, Bower James, Saraiva Margarida, Vaconcellos Sidra E G, Suffys Philip, Koch Anastasia, Wilkinson Robert, Gail-Bekker Linda, Malla Bijaya, Ley Serej D, Beck Hans-Peter, de Jong Bouke C, Toit Kadri, Sanchez-Padilla Elisabeth, Bonnet Maryline, Gil-Brusola Ana, Frank Matthias, Penlap Beng Veronique N, Eisenach Kathleen, Alani Issam, Wangui Ndung'u Perpetual, Revathi Gunturu, Gehre Florian, Akter Suriya, Ntoumi Francine, Stewart-Isherwood Lynsey, Ntinginya Nyanda E, Rachow Andrea, Hoelscher Michael, Cirillo Daniela Maria, Skenders Girts, Hoffner Sven, Bakonyte Daiva, Stakenas Petras, Diel Roland, Crudu Valeriu, Moldovan Olga, Al-Hajoj Sahal, Otero Larissa, Barletta Francesca, Jane Carter E, Diero Lameck, Supply Philip, Comas Iñaki, Niemann Stefan, Gagneux Sebastien. Mycobacterium tuberculosis lineage 4 comprises globally distributed and geographically restricted sublineages.. Nature genetics. 2016. DOI: 10.1038/ng.3704.

Предметные рубрики MeSH

DNA, BacterialGenomicsGenotypeGlobal HealthHumansMycobacterium tuberculosisPhylogeographyPolymorphism, GeneticTuberculosis
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