Amphetamine abuse and transsexualism.

The serendipitous findings of an unusual case of self-labeled transsexualism and amphetamine abuse are presented. The patient, a white male, reported transsexual episodes only after intravenous injection of metamphetamines. At all other times, he considered himself masculine and never entertained cross-gender fantasies or wishes for sex reassignment surgery. Hypotheses are raised which suggest a possible neurochemical explanation for this man's transsexual episodes.