Revista do Instituto de Medicina Tropical de Sao Paulo · 2014
First report on ototoxicity of meglumine antimoniate.
Клинический случайСтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
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Valete-Rosalino Cláudia Maria, Araujo-Melo Maria Helena, Bezerra Débora Cristina de Oliveira, Barcelos Renata Oliveira de, Melo-Ferreira Vanessa de, Torraca Tânia Salgado de Sousa, Martins Ana Cristina da Costa, Moreira João Soares, Vargas Mirian Catherine Melgares, Braga Frederico Pereira Bom, Salgueiro Mariza de Matos, Saheki Maurício Naoto, Schubach Armando Oliveira
Аннотация
INTRODUCTION: Pentavalent antimonials are the first drug of choice in the treatment of tegumentary leishmaniasis. Data on ototoxicity related with such drugs is scarcely available in literature, leading us to develop a study on cochleovestibular functions.
CASE REPORT: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted.
CONCLUSION: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.
CASE REPORT: A case of a tegumentary leishmaniasis patient, a 78-year-old man who presented a substantial increase in auditory threshold with tinnitus and severe rotatory dizziness during the treatment with meglumine antimoniate, is reported. These symptoms worsened in two weeks after treatment was interrupted.
CONCLUSION: Dizziness and tinnitus had already been related to meglumine antimoniate. However, this is the first well documented case of cochlear-vestibular toxicity related to meglumine antimoniate.