Journal of neurovirology · 1997
C2H2-546: a zinc finger protein differentially expressed in HTLV-1 infected T cells.
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Drew P D, Gado A M, Canning R D, Nagle J W, Dehejia A M, Polymeropoulos M H, Biddison W E, Jacobson S, Becker K G
Аннотация
We report the cloning and characterization of a novel cDNA termed C2H2-546 which encodes a C2H2-type zinc finger protein. C2H2-546 RNA is expressed in the HTLV-1 infected T cells examined which were derived from HAM-TSP patients, but not in T cells derived from ATL patients. The C2H2-546 gene is conserved in humans and primates and maps to chromosome 10q11.2, a site associated with a variety of cancers. Thus, C2H2-546 is a candidate regulatory molecule important in the formation of these tumors, and may serve as an important marker to distinguish HTLV-1 infected ATL versus HAM-TSP T cell lineages.
Предметные рубрики MeSH
Amino Acid SequenceAnimalsBase SequenceChromosomes, Artificial, YeastChromosomes, Human, Pair 10DNA, ComplementaryDrosophila melanogasterGene Expression Regulation, ViralGenesHTLV-I InfectionsHuman T-lymphotropic virus 1HumansKruppel-Like Transcription FactorsLeukemia-Lymphoma, Adult T-CellMammalsMolecular Sequence DataNeoplasm ProteinsNuclear ProteinsParaparesis, Tropical SpasticPolymerase Chain ReactionSaccharomyces cerevisiaeSpecies SpecificityT-LymphocytesTranscription FactorsTumor Cells, CulturedZinc Fingers