Archives of medical research · 2018
Meta-analysis on the Association Between Norepinephrine Transporter Gene rs2242446, rs5569 Polymorphisms and Risk of Major Depressive Disorder.
СтатьяМетаанализНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Rui Huan, Qian Hongjia, Shi Muhua, Zhang Guorui, Wang Liqun
Аннотация
BACKGROUND AND AIMS: The association between norepinephrine transporter (NET) gene polymorphisms and the risk of major depressive disorder (MDD) has been investigated extensively, but with contradictory findings.
MATERIALS/METHODS: To clarify such contradiction, a comprehensive meta-analysis was conducted by searching PubMed, EMBASE, Web of Science and China Knowledge Resource Integrated Database. Odd ratios (ORs) and 95% confidence intervals (Cis) were used to evaluate the strength of the association.
RESULTS: Totally 23 case-control studies regarding rs2242446 and rs5569 polymorphisms were included. Overall analysis and subgroup analysis indicated no significant association between NET gene rs2242446 polymorphism and MDD risk. However, recessive and homozygous models revealed a significant association between NET rs5569 polymorphism and increased risk of MDD. The stratified analysis further indicated significant associations in Asians, hospital-based studies and studies with other genotyping methods.
CONCLUSIONS: In conclusion, NET gene rs5569 polymorphism could increase the risk of MDD, especially among Asians.
MATERIALS/METHODS: To clarify such contradiction, a comprehensive meta-analysis was conducted by searching PubMed, EMBASE, Web of Science and China Knowledge Resource Integrated Database. Odd ratios (ORs) and 95% confidence intervals (Cis) were used to evaluate the strength of the association.
RESULTS: Totally 23 case-control studies regarding rs2242446 and rs5569 polymorphisms were included. Overall analysis and subgroup analysis indicated no significant association between NET gene rs2242446 polymorphism and MDD risk. However, recessive and homozygous models revealed a significant association between NET rs5569 polymorphism and increased risk of MDD. The stratified analysis further indicated significant associations in Asians, hospital-based studies and studies with other genotyping methods.
CONCLUSIONS: In conclusion, NET gene rs5569 polymorphism could increase the risk of MDD, especially among Asians.