Journal of neurology · 2004
Motor cortex excitability in transient global amnesia.
Сравнительное исследованиеСтатьяНазвание и аннотация: Перевод пока не подготовлен
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Nardone Raffaele, Buffone Ebba C, Matullo Massimo F, Tezzon Frediano
Аннотация
OBJECTIVE: To investigate the physiology of motor cortical areas in patients with transient global amnesia (TGA).
MATERIALS AND METHODS: We performed transcranial magnetic stimulation (TMS) and single photon emission computed tomography (SPECT) in 13 patients during and after the acute phase of a typical episode of TGA. Measures of cortical excitability included motor threshold (MT) to magnetic stimulation, cortical silent period (SP) duration and intracortical inhibition (ICI) using a paired-pulse TMS technique.
RESULTS: We found thalamic hypoperfusion and an ipsilateral significantly decreased ICI during the acute phase of TGA.
CONCLUSIONS: Reduced activity in inhibitory circuits may explain why PET studies of patients with TGA showed neocortical hypometabolism. Our findings are consistent with the hypothesis that frontal cortex dysfunction probably due to damage affecting the thalamocortical circuits may play an important role in the pathogenesis of the syndrome.
MATERIALS AND METHODS: We performed transcranial magnetic stimulation (TMS) and single photon emission computed tomography (SPECT) in 13 patients during and after the acute phase of a typical episode of TGA. Measures of cortical excitability included motor threshold (MT) to magnetic stimulation, cortical silent period (SP) duration and intracortical inhibition (ICI) using a paired-pulse TMS technique.
RESULTS: We found thalamic hypoperfusion and an ipsilateral significantly decreased ICI during the acute phase of TGA.
CONCLUSIONS: Reduced activity in inhibitory circuits may explain why PET studies of patients with TGA showed neocortical hypometabolism. Our findings are consistent with the hypothesis that frontal cortex dysfunction probably due to damage affecting the thalamocortical circuits may play an important role in the pathogenesis of the syndrome.
Предметные рубрики MeSH
AdultAgedAmnesia, Transient GlobalAnalysis of VarianceCase-Control StudiesElectric StimulationFemaleFunctional LateralityHumansMagneticsMaleMiddle AgedMotor CortexNeural ConductionNeural InhibitionNeuropsychological TestsReaction TimeSensory ThresholdsTime FactorsTomography, Emission-Computed, Single-Photon