Ocular immunology and inflammation · 2009
Recalcitrant granulomatous sclerouveitis in a patient with granulomatous ANCA-associated vasculitis.
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Levy-Clarke Grace, Ding Xiaoyan, Gangaputra Sapna, Yeh Steven, Goodglick Todd, Byrnes Gordon, Nussenblatt Robert, Chan Chi-Chao
Аннотация
PURPOSE: To report an unusual case of granulomatous sclerochoroiditis.
DESIGN: Interventional case report.
METHODS: A patient with ANCA-associated granulomatous vasculitis presented with nodular necrotizing scleritis, which was recalcitrant to multiple systemic immunosuppressive therapies and progressed to a blind painful eye, which was enucleated.
RESULTS: Histopathology revealed extensive occlusive vasculitis, diffuse T- and B- cellular infiltration, and lymphoid granulomatous formation. Enhanced MHC class II antigens, adhesion molecules, and Fas (CD95) and FasL (CD95L) were detected in the lesion.
CONCLUSION: Granulomatous sclerochoroiditis with aggressive immune reaction can be a complication of ANCA-associated granulomatous vasculitis.
DESIGN: Interventional case report.
METHODS: A patient with ANCA-associated granulomatous vasculitis presented with nodular necrotizing scleritis, which was recalcitrant to multiple systemic immunosuppressive therapies and progressed to a blind painful eye, which was enucleated.
RESULTS: Histopathology revealed extensive occlusive vasculitis, diffuse T- and B- cellular infiltration, and lymphoid granulomatous formation. Enhanced MHC class II antigens, adhesion molecules, and Fas (CD95) and FasL (CD95L) were detected in the lesion.
CONCLUSION: Granulomatous sclerochoroiditis with aggressive immune reaction can be a complication of ANCA-associated granulomatous vasculitis.