Enhanced S-cone syndrome with subfoveal neovascularization.

PURPOSE: To report a case of enhanced S-cone syndrome associated with subfoveal neovascularization.

DESIGN

Observational case report.

METHODS

A 23-year-old man, who was first examined at age 9 years, was found to have enhanced S-cone syndrome by clinical, electrophysiological, and molecular genetic examinations.

RESULTS

At 9 years of age, a subfoveal neovascularization was present in his right eye and corrected visual acuity was RE: 0.15 and LE: 1.0. After he was 20 years old, cystoid changes in the macula of the left eye appeared and visual acuity, in the left eye, decreased from 1.0 to 0.02.

CONCLUSION

The clinical course of enhanced S-cone syndrome is progressive, and we suggest that the subretinal neovascularization is a phenotypic variation of enhanced S-cone syndrome.