Internal medicine (Tokyo, Japan) · 1999
Cancer-associated retinopathy during treatment for small-cell lung carcinoma.
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Kashiwabara K, Nakamura H, Kishi K, Yagyu H, Sarashina G, Kobayashi K, Matsuoka T
Аннотация
A 70-year-old woman with small-cell lung carcinoma (c-T4N2M0) was treated by six courses of combination chemotherapy (carboplatin and etoposide). After two weeks, she complained of a sense of darkness and night blindness. A Western blot analysis showed that the patient's serum bound with the recombinant 23-kDa retinal cancer-associated retinopathy (CAR) antigen at 1:1,000 dilution. Her visual acuity became so poor that she could only recognise a hand motion at 50 cm despite treatment with corticosteroids and combination chemotherapy. The patient was diagnosed as having a rare type of CAR because CAR is usually found before the diagnosis of primary cancer.
Предметные рубрики MeSH
Adrenal Cortex HormonesAgedAntigens, NeoplasmAntineoplastic Combined Chemotherapy ProtocolsCalcium-Binding ProteinsCarboplatinCarcinoma, Small CellEtoposideEye ProteinsFemaleHippocalcinHumansImmunosuppressive AgentsLipoproteinsLung NeoplasmsNerve Tissue ProteinsParaneoplastic SyndromesRecoverinRetinal DiseasesVision, LowVisual Acuity