Progress in neuro-psychopharmacology & biological psychiatry · 2008
SCN8A as a novel candidate gene associated with bipolar disorder in the Han Chinese population.
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Wang Yang, Zhang Jing, Li Xingwang, Ji Jue, Yang Fengping, Wan Chunling, Feng Guoyin, Wan Peng, He Lin, He Guang
Аннотация
BACKGROUND: Bipolar disorder (BPD) is a common, severe and recurrent psychiatric disorder. It has been suggested that BPD patients have a higher risk of suicide than patients with any other psychiatric illnesses. A recent study found that suicide attempt was associated with the SCN8A gene, which has been mapped close to one of the BPD susceptibility loci. Thus, SCN8A is likely to be a candidate gene for BPD.
METHODS: In this study, three SNPs (rs1601012, rs303810, rs60637) were analyzed in 506 bipolar patients and 507 controls of Han origin.
RESULTS: We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p=0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs.
CONCLUSION: Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population.
METHODS: In this study, three SNPs (rs1601012, rs303810, rs60637) were analyzed in 506 bipolar patients and 507 controls of Han origin.
RESULTS: We found that two individual SNPs showed statistically significant differences between cases and controls in both allele and genotype distribution, but only rs303810 was still significant in allele distribution (p=0.0164) after correction. No obvious linkage disequilibrium or haplotypes were observed among these SNPs.
CONCLUSION: Our results indicate that SCN8A may be a potential susceptibility gene for bipolar disorder in the Han Chinese population.