Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al] · 2008
Complete remission after neoadjuvant chemoradiation in a stage IV vulvar cancer patient.
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Bischoff Annett, Marnitz Simone, Köhler Christhardt, Kurzeja Roberto, Morawietz Lars, Schneider Achim, Budach Volker
Аннотация
BACKGROUND: Surgery is the standard in the management of vulvar cancer. Several studies assessed the feasibility of radiochemotherapy as definitive therapy and/or neoadjuvant procedure in order to limit the extent of surgery. Combined radiochemotherapy is associated with considerable toxicity. The authors report on a modified neoadjuvant radiochemotherapy schedule which is isoeffective to the GOG (Gynecologic Oncology Group) protocol, but associated with less therapy-related toxicity.
CASE REPORT: A 36-year-old woman with stage IV vulvar cancer and long-distance rectal infiltration is reported. Laparoscopic pretherapeutic staging confirmed pelvic and paraaortic lymph node metastases.
RESULT: The patient received a neoadjuvant radiochemotherapy. After complete remission, a simple vulvectomy carried out 3 months later showed no evidence of tumor. Up to now, there is no evidence of tumor progression or recurrence.
CONCLUSION: Preoperative conventionally fractionated simultaneous radiochemotherapy seems to be a feasible and safe treatment option for patients with locally advanced vulvar cancer in order to avoid exenterative surgery.
CASE REPORT: A 36-year-old woman with stage IV vulvar cancer and long-distance rectal infiltration is reported. Laparoscopic pretherapeutic staging confirmed pelvic and paraaortic lymph node metastases.
RESULT: The patient received a neoadjuvant radiochemotherapy. After complete remission, a simple vulvectomy carried out 3 months later showed no evidence of tumor. Up to now, there is no evidence of tumor progression or recurrence.
CONCLUSION: Preoperative conventionally fractionated simultaneous radiochemotherapy seems to be a feasible and safe treatment option for patients with locally advanced vulvar cancer in order to avoid exenterative surgery.
Предметные рубрики MeSH
AdultAntineoplastic Combined Chemotherapy ProtocolsBowen's DiseaseCarcinoma, Squamous CellCombined Modality TherapyFemaleHuman papillomavirus 16HumansLymph NodesLymphatic MetastasisNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm Recurrence, LocalNeoplasm StagingNeoplasms, Multiple PrimaryPapillomavirus InfectionsRadiation InjuriesRectumSkin NeoplasmsUterine Cervical NeoplasmsVulvaVulvar Neoplasms