Oncology · 2008
Association of E1AF mRNA expression with tumor progression and matrilysin in human rectal cancer.
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Liu Hai-Yi, Zhou Bin, Wang Ling, Li Yuan, Zhou Zong-Guang, Sun Xiao-Feng, Xu Bing, Zeng Yu-Jian, Song Jun-Min, Luo Hong-Zhi, Yang Lie
Аннотация
OBJECTIVE: To examine E1AF mRNA expression and to determine whether it is correlated with tumor progression and matrilysin in human rectal cancer.
METHODS: Real-time RT-PCR was used to determine E1AF and matrilysin expression in 100 matched rectal cancers and normal tissues.
RESULTS: Among the 100 rectal cancers, 69 cases of E1AF mRNA overexpression were observed. E1AF mRNA overexpression correlated well with matrilysin. In carcinomas, E1AF mRNA overexpression correlated significantly with depth of invasion, lymph node metastasis, venous involvement and advanced pTNM stage.
CONCLUSIONS: E1AF was correlated significantly with tumor progression of human rectal cancer and may be an important factor in rectal cancer progression.
METHODS: Real-time RT-PCR was used to determine E1AF and matrilysin expression in 100 matched rectal cancers and normal tissues.
RESULTS: Among the 100 rectal cancers, 69 cases of E1AF mRNA overexpression were observed. E1AF mRNA overexpression correlated well with matrilysin. In carcinomas, E1AF mRNA overexpression correlated significantly with depth of invasion, lymph node metastasis, venous involvement and advanced pTNM stage.
CONCLUSIONS: E1AF was correlated significantly with tumor progression of human rectal cancer and may be an important factor in rectal cancer progression.
Предметные рубрики MeSH
Adenovirus E1A ProteinsAgedDisease ProgressionFemaleGene Expression Regulation, NeoplasticHumansMaleMatrix Metalloproteinase 7Middle AgedNeoplasm InvasivenessNeoplasm StagingProto-Oncogene ProteinsProto-Oncogene Proteins c-etsRNA, MessengerRNA, NeoplasmRectal NeoplasmsRectumReverse Transcriptase Polymerase Chain Reaction