Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association · 2026
Temporal association between NRF2/HO-1 activation, endogenous BDNF up-regulation, and motor recovery in a male mouse MCAO model.
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Park Junghee, Hwang Hyoin, Shin Hyekyoung, Chung Yoonyoung, Kim Dongjoon, Jun Yonghyun
Аннотация
BACKGROUND: Stroke induces severe neurological impairment, however, there is limited understanding of the mechanisms underlying post-stroke recovery. Nuclear factor erythroid 2-related factor 2 (NRF2) and brain-derived neurotrophic factor (BDNF) have been implicated in tissue responses to ischemic injury; however, their temporal interactions in middle cerebral artery occlusion (MCAO) models are not fully understood.
METHODS: Male C57BL/6 mice (7-8 weeks) were subjected to transient MCAO (tMCAO). Motor behavior, cerebral blood flow, and temporal changes in NRF2, heme oxygenase-1 (HO-1), and BDNF expression were assessed over 14 days.
RESULTS: Cerebral blood flow in the ischemic cortex remained significantly reduced for up to 14 days after MCAO. Motor deficits were most severe on day 3 and showed gradual recovery by day 7. NRF2 expression peaked on day 3, whereas HO-1 and BDNF expression increased on days 7 and 14, coinciding with improved motor performance and increased neuronal preservation.
CONCLUSION: These findings indicate that activation of the NRF2/HO-1 pathway is temporally associated with increased expression of endogenous BDNF and recovery of motor function following ischemic injury in male mice.
METHODS: Male C57BL/6 mice (7-8 weeks) were subjected to transient MCAO (tMCAO). Motor behavior, cerebral blood flow, and temporal changes in NRF2, heme oxygenase-1 (HO-1), and BDNF expression were assessed over 14 days.
RESULTS: Cerebral blood flow in the ischemic cortex remained significantly reduced for up to 14 days after MCAO. Motor deficits were most severe on day 3 and showed gradual recovery by day 7. NRF2 expression peaked on day 3, whereas HO-1 and BDNF expression increased on days 7 and 14, coinciding with improved motor performance and increased neuronal preservation.
CONCLUSION: These findings indicate that activation of the NRF2/HO-1 pathway is temporally associated with increased expression of endogenous BDNF and recovery of motor function following ischemic injury in male mice.