[Expression and Clinical Significance of Eukaryotic Initiation Factor 4E in Newly Diagnosed Patients with Multiple Myeloma].

OBJECTIVE

To explore the expression and clinical significance of eukaryotic translation initiation factor 4E(eIF4E) in bone marrow samples of newly diagnosed multiple myeloma (NDMM) patients.

METHODS

Immunohistochemical staining was used to analyze the expression of eIF4E protein in bone marrow biopsy samples from 75 NDMM patients and 25 patients with benign bone marrow disease. Clinical data were collected to analyze the correlation between eIF4E protein expression and clinical features and its prognostic significance in bone marrow samples of NDMM patients.

RESULTS

The positive rate of eIF4E protein expression in bone marrow samples of NDMM patients was higher than that in patients with benign bone marrow disease (P<0.001). Positive expression of eIF4E protein was correlated with elevated serum lactate dehydrogenase in MM patients. Univariate and multivariate analysis showed that positive expression of eIF4E protein was significantly associated with shortened overall survival (OS) in NDMM patients, and was an independent risk factor affecting OS in NDMM patients.

CONCLUSION

Positive expression of eIF4E protein is an independent poor prognostic factor for OS in NDMM patients.