Internal medicine (Tokyo, Japan) · 2025
Persistent Unilateral Pleural Effusion with Chimeric Antigen Receptor T-cell Infiltration in Primary Mediastinal Large B-cell Lymphoma.
СтатьяКлинический случайНазвание и аннотация: Перевод пока не подготовлен
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Hayashi Hiroyoshi, Sakurai Masatoshi, Sakamoto Miki, Shindo Takahide, Koya Junji, Shiozawa Yuka, Masuda Kyoko, Yamaguchi Kentaro, Kawase Honomi, Miyata Jun, Matsushita Hiromichi, Yamazaki Rie, Koda Yuya, Kato Jun, Kataoka Keisuke
Аннотация
Pleural effusion following chimeric antigen receptor (CAR) T-cell therapy is typically transient, bilateral, and associated with cytokine release syndrome. We herein report persistent unilateral massive pleural effusion with CAR T-cell infiltration in a 34-year-old man with refractory primary mediastinal large B-cell lymphoma involving pleural lesions treated with axicabtagene ciloleucel. Flow cytometry confirmed CAR T-cell infiltration into the pleural fluid. Although temporarily improved by corticosteroids, the effusion persisted for several months but eventually resolved spontaneously. Physicians should consider CAR T-cell infiltration in persistent unilateral pleural effusion after CAR T-cell therapy, emphasizing the importance of flow cytometry for the diagnosis and potential spontaneous resolution without corticosteroids.