Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2004
[The expression of urokinase-type plasminogen activator and its receptor in urinary transitional cell carcinoma].
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Li Yan-Jiang, Zheng Bao-zhong, Zhou Zun-lin
Аннотация
OBJECTIVE: To probe into the expression and clinical significance of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in urinary transitional cell carcinoma.
METHODS: Expression of uPA and uPAR were detected in 50 cases of renal pelvis and ureter carcinoma and 40 cases of bladder cancer immunohistochemically.
RESULTS: The positive rates of uPA and uPAR were closely correlated to the grade and the stage of urinary transitional cell carcinoma (r = 0.979, P < 0.01), whereas uPA and uPAR were not detected in normal kidney, ureter and bladder tissue.
CONCLUSION: uPA and uPAR are highly expressed in urinary transitional cell carcinoma and they may be responsible for the tumor invasion and metastasis.
METHODS: Expression of uPA and uPAR were detected in 50 cases of renal pelvis and ureter carcinoma and 40 cases of bladder cancer immunohistochemically.
RESULTS: The positive rates of uPA and uPAR were closely correlated to the grade and the stage of urinary transitional cell carcinoma (r = 0.979, P < 0.01), whereas uPA and uPAR were not detected in normal kidney, ureter and bladder tissue.
CONCLUSION: uPA and uPAR are highly expressed in urinary transitional cell carcinoma and they may be responsible for the tumor invasion and metastasis.
Предметные рубрики MeSH
AdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, Transitional CellFemaleHumansKidney NeoplasmsLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm StagingPrognosisReceptors, Cell SurfaceReceptors, Urokinase Plasminogen ActivatorUrinary Bladder NeoplasmsUrokinase-Type Plasminogen Activator