Медицинская библиотека · Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition · 2004

[The expression of urokinase-type plasminogen activator and its receptor in urinary transitional cell carcinoma].

Li Yan-Jiang, Zheng Bao-zhong, Zhou Zun-lin

Аннотация на английскомСтатьяПеревод пока не подготовлен

Аннотация

OBJECTIVE

To probe into the expression and clinical significance of urokinase-type plasminogen activator (uPA) and its receptor (uPAR) in urinary transitional cell carcinoma.

METHODS

Expression of uPA and uPAR were detected in 50 cases of renal pelvis and ureter carcinoma and 40 cases of bladder cancer immunohistochemically.

RESULTS

The positive rates of uPA and uPAR were closely correlated to the grade and the stage of urinary transitional cell carcinoma (r = 0.979, P < 0.01), whereas uPA and uPAR were not detected in normal kidney, ureter and bladder tissue.

CONCLUSION

uPA and uPAR are highly expressed in urinary transitional cell carcinoma and they may be responsible for the tumor invasion and metastasis.

Для цитирования: Li Yan-Jiang, Zheng Bao-zhong, Zhou Zun-lin. [The expression of urokinase-type plasminogen activator and its receptor in urinary transitional cell carcinoma].. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition. 2004.

Предметные рубрики MeSH

Adult Aged Aged, 80 and over Biomarkers, Tumor Carcinoma, Transitional Cell Female Humans Kidney Neoplasms Lymphatic Metastasis Male Middle Aged Neoplasm Invasiveness Neoplasm Staging Prognosis Receptors, Cell Surface Receptors, Urokinase Plasminogen Activator Urinary Bladder Neoplasms Urokinase-Type Plasminogen Activator

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