Hepatology research : the official journal of the Japan Society of Hepatology · 2001
A case of agranulocytosis associated with severe acute hepatitis B.
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Iwamoto J -i., Hakozaki Y, Sakuta H, Kobari S -i., Kayashima S, Fujioka T, Ooba K -i., Shirahama T
Аннотация
A 29-year-old male patient with acute hepatitis B developed agranulocytosis about 2 months after the clinical onset of the hepatitis. Bone marrow examination showed hypercellularity and maturation arrest of myeloid leukogenesis at the stage of metamyelocyte. Anti-neutrophil antibody was negative. Since the patient did not show spontaneous recovery for 2 months, the patient received granulocyte-colony stimulating factor, but the therapy was a very short course because he had an elevation of temperature and nausea. Sixty-eight days after admission, he was started on lithium carbonate at a dose of 600 mg per day. About 3 weeks later, peripheral granulocyte counts had recovered to normal level.