The British journal of psychiatry : the journal of mental science · 1999
Active monitoring of 12,760 clozapine recipients in the UK and Ireland. Beyond pharmacovigilance.
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Munro J, O'Sullivan D, Andrews C, Arana A, Mortimer A, Kerwin R
Аннотация
BACKGROUND: People prescribed clozapine for treatment-resistant schizophrenia have mandatory haematological monitoring through a case register for identifying reversible neutropenia.
AIMS: To quantify risk factors for agranulocytosis in subjects receiving clozapine.
METHOD: Data from 12,760 subjects registered to receive clozapine from January 1990 to April 1997 were analysed. Risk factors for agranulocytosis were quantified using a Cox proportional-hazards regression analysis.
RESULTS: The risk for agranulocytosis in Asian subjects was 2.4 times that in Caucasians (P = 0.03). There was an age-related increase in risk of 53% per decade (P = 0.0001).
CONCLUSIONS: The case register yielded valuable information for guiding research into the causes of the haematological reactions.
AIMS: To quantify risk factors for agranulocytosis in subjects receiving clozapine.
METHOD: Data from 12,760 subjects registered to receive clozapine from January 1990 to April 1997 were analysed. Risk factors for agranulocytosis were quantified using a Cox proportional-hazards regression analysis.
RESULTS: The risk for agranulocytosis in Asian subjects was 2.4 times that in Caucasians (P = 0.03). There was an age-related increase in risk of 53% per decade (P = 0.0001).
CONCLUSIONS: The case register yielded valuable information for guiding research into the causes of the haematological reactions.