Oxford medical case reports · 2025
Anastrozole-induced autoimmune hepatitis: a rare case report and literature review.
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Haghollahi Shahab, Wood Rebecca M, Ould Ismail Abdol Aziz, Ren Bing, Afzal Muhammad Z
Аннотация
BACKGROUND: Anastrozole, an aromatase inhibitor (AI), has been used extensively for the treatment of estrogen receptor-positive breast cancer. Autoimmune hepatitis (AIH) is an extremely rare but serious complication of anastrozole treatment.
CASE DESCRIPTION: We present the case of an 81-year-old female who presented with significantly elevated liver function test (LFTs) results 8 months after the initiation of anastrozole for early-stage breast cancer. Serological and liver biopsy findings were consistent with AIH. Discontinuation of anastrozole, along with a short course of steroids, resulted in rapid clinical improvement and normalization of both LFTs and autoantibodies.
CONCLUSION: Clinicians should be aware of drug-induced AIH as a rare but life-threatening complication of anastrozole and potentially other aromatase inhibitors.
CASE DESCRIPTION: We present the case of an 81-year-old female who presented with significantly elevated liver function test (LFTs) results 8 months after the initiation of anastrozole for early-stage breast cancer. Serological and liver biopsy findings were consistent with AIH. Discontinuation of anastrozole, along with a short course of steroids, resulted in rapid clinical improvement and normalization of both LFTs and autoantibodies.
CONCLUSION: Clinicians should be aware of drug-induced AIH as a rare but life-threatening complication of anastrozole and potentially other aromatase inhibitors.