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DOI 10.1007/s40292-023-00602-4

Медицинская библиотека · High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension · 2023

The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.

Maloberti Alessandro, Mengozzi Alessandro, Russo Elisa, Cicero Arrigo Francesco Giuseppe, Angeli Fabio, Agabiti Rosei Enrico, Barbagallo Carlo Maria, Bernardino Bruno, Bombelli Michele, Cappelli Federica, Casiglia Edoardo, Cianci Rosario, Ciccarelli Michele, Cirillo Massimo, Cirillo Pietro, Desideri Giovambattista, D'Elia Lanfranco, Dell'Oro Raffaella, Facchetti Rita, Ferri Claudio, Galletti Ferruccio, Giannattasio Cristina, Gesualdo Loreto, Iaccarino Guido, Lippa Luciano, Mallamaci Francesca, Masi Stefano, Masulli Maria, Mazza Alberto, Muiesan Maria Lorenza, Nazzaro Pietro, Parati Gianfranco, Palatini Paolo, Pauletto Paolo, Pontremoli Roberto, Pugliese Nicola Riccardo, Quarti-Trevano Fosca, Rattazzi Marcello, Reboldi Gianpaolo, Rivasi Giulia, Salvetti Massimo, Tikhonoff Valerie, Tocci Giuliano, Ungar Andrea, Verdecchia Paolo, Viazzi Francesca, Volpe Massimo, Virdis Agostino, Grassi Guido, Borghi Claudio, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA)

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Аннотация

The relationship between Serum Uric Acid (UA) and Cardiovascular (CV) diseases has already been extensively evaluated, and it was found to be an independent predictor of all-cause and cardiovascular mortality but also acute coronary syndrome, stroke and heart failure. Similarly, also many papers have been published on the association between UA and kidney function, while less is known on the role of UA in metabolic derangement and, particularly, in metabolic syndrome. Despite the substantial number of publications on the topic, there are still some elements of doubt: (1) the better cut-off to be used to refine CV risk (also called CV cut-off); (2) the needing for a correction of UA values for kidney function; and (3) the better definition of its role in metabolic syndrome: is UA simply a marker, a bystander or a key pathological element of metabolic dysregulation?. The Uric acid Right for heArt Health (URRAH) project was designed by the Working Group on uric acid and CV risk of the Italian Society of Hypertension to answer the first question. After the first papers that individuates specific cut-off for different CV disease, subsequent articles have been published responding to the other relevant questions. This review will summarise most of the results obtained so far from the URRAH research project.

Для цитирования: Maloberti Alessandro, Mengozzi Alessandro, Russo Elisa, Cicero Arrigo Francesco Giuseppe, Angeli Fabio, Agabiti Rosei Enrico, Barbagallo Carlo Maria, Bernardino Bruno, Bombelli Michele, Cappelli Federica, Casiglia Edoardo, Cianci Rosario, Ciccarelli Michele, Cirillo Massimo, Cirillo Pietro, Desideri Giovambattista, D'Elia Lanfranco, Dell'Oro Raffaella, Facchetti Rita, Ferri Claudio, Galletti Ferruccio, Giannattasio Cristina, Gesualdo Loreto, Iaccarino Guido, Lippa Luciano, Mallamaci Francesca, Masi Stefano, Masulli Maria, Mazza Alberto, Muiesan Maria Lorenza, Nazzaro Pietro, Parati Gianfranco, Palatini Paolo, Pauletto Paolo, Pontremoli Roberto, Pugliese Nicola Riccardo, Quarti-Trevano Fosca, Rattazzi Marcello, Reboldi Gianpaolo, Rivasi Giulia, Salvetti Massimo, Tikhonoff Valerie, Tocci Giuliano, Ungar Andrea, Verdecchia Paolo, Viazzi Francesca, Volpe Massimo, Virdis Agostino, Grassi Guido, Borghi Claudio, Working Group on Uric Acid and Cardiovascular Risk of the Italian Society of Hypertension (SIIA). The Results of the URRAH (Uric Acid Right for Heart Health) Project: A Focus on Hyperuricemia in Relation to Cardiovascular and Kidney Disease and its Role in Metabolic Dysregulation.. High blood pressure & cardiovascular prevention : the official journal of the Italian Society of Hypertension. 2023. DOI: 10.1007/s40292-023-00602-4.

Предметные рубрики MeSH

HumansHyperuricemiaUric AcidRisk FactorsMetabolic SyndromeKidney DiseasesAcute Coronary Syndrome
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