Canadian journal of ophthalmology. Journal canadien d'ophtalmologie · 2025
Geographic atrophy in Korean patients with dry age-related macular degeneration: incidence, phenotypes, and progression.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Han Ye Eun, Choi Hoon Il, Lee Junyeop, Kim Yoon Jeon, Lee Joo Yong, Sadda Srinivas R, Yoon Young Hee
Аннотация
OBJECTIVE: To evaluate the characteristics of geographic atrophy (GA) in Korean patients, including incidence, phenotypes, progression patterns, and factors associated with progression rates.
DESIGN: Retrospective longitudinal cohort study.
PARTICIPANTS: Korean patients with intermediate and advanced (prevalent GA) dry AMD, followed for ≥3 years.
METHODS: GA incidence was defined as the percentage of new GA emerging from the intermediate dry AMD group during the follow-up. Baseline phenotypes were evaluated in the prevalent GA group at the initial visit using fundus photography, spectral-domain optical coherence tomography, and fundus autofluorescence (FAF). Progression patterns were assessed by growth rates (mm2/year and mm/year using square-root treansformation [SQRT]), and the centripetal growth direction (foveal involvement of extrafoveal lesions). Linear regression was used to identify factors associated with progression rates.
RESULTS: In intermediate dry AMD group (395 eyes/241 patients), GA incidence was 6.8%, while wet conversion was 14.4%, during 60.5 ± 13.5 months. In prevalent GA group (70 eyes/46 patients), the mean lesion size was 7.2 ± 7.1 mm2 (2.4 ± 1.3 mm [SQRT]), with bilateral involvement in 68.6%, banded/diffuse FAF patterns in 81.4%, extrafoveal and multifocal locations in 51.4% and 84.3%, and drusen and reticular pseudodrusen in 87.1% and 34.3%. The progression rate was 2.0 ± 1.3 mm2/year (0.3 ± 0.2 mm/year [SQRT]), with 69.4% exhibiting centripetal direction during 61.2 ± 14.5 months. Large lesion size, banded/diffuse FAF patterns, and extrafoveal locations were positively associated with progression rates (p = 0.006, 0.007, and 0.008).
CONCLUSIONS: The 5-year incidence of GA in Korean patients with intermediate dry AMD was 6.8%, approximately half of the rate of wet conversion. The mean GA progression rate was 2.0 mm2/year (0.3 mm/year [SQRT]). Risk factors for fast progression were banded/diffuse FAF patterns, extrafoveal locations, and large lesion size.
DESIGN: Retrospective longitudinal cohort study.
PARTICIPANTS: Korean patients with intermediate and advanced (prevalent GA) dry AMD, followed for ≥3 years.
METHODS: GA incidence was defined as the percentage of new GA emerging from the intermediate dry AMD group during the follow-up. Baseline phenotypes were evaluated in the prevalent GA group at the initial visit using fundus photography, spectral-domain optical coherence tomography, and fundus autofluorescence (FAF). Progression patterns were assessed by growth rates (mm2/year and mm/year using square-root treansformation [SQRT]), and the centripetal growth direction (foveal involvement of extrafoveal lesions). Linear regression was used to identify factors associated with progression rates.
RESULTS: In intermediate dry AMD group (395 eyes/241 patients), GA incidence was 6.8%, while wet conversion was 14.4%, during 60.5 ± 13.5 months. In prevalent GA group (70 eyes/46 patients), the mean lesion size was 7.2 ± 7.1 mm2 (2.4 ± 1.3 mm [SQRT]), with bilateral involvement in 68.6%, banded/diffuse FAF patterns in 81.4%, extrafoveal and multifocal locations in 51.4% and 84.3%, and drusen and reticular pseudodrusen in 87.1% and 34.3%. The progression rate was 2.0 ± 1.3 mm2/year (0.3 ± 0.2 mm/year [SQRT]), with 69.4% exhibiting centripetal direction during 61.2 ± 14.5 months. Large lesion size, banded/diffuse FAF patterns, and extrafoveal locations were positively associated with progression rates (p = 0.006, 0.007, and 0.008).
CONCLUSIONS: The 5-year incidence of GA in Korean patients with intermediate dry AMD was 6.8%, approximately half of the rate of wet conversion. The mean GA progression rate was 2.0 mm2/year (0.3 mm/year [SQRT]). Risk factors for fast progression were banded/diffuse FAF patterns, extrafoveal locations, and large lesion size.