Nature communications · 2025
Host-microbe multiomic profiling identifies distinct COVID-19 immune dysregulation in solid organ transplant recipients.
СтатьяМногоцентровое исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Pickering Harry, Schaenman Joanna, Phan Hoang Van, Maguire Cole, Tsitsiklis Alexandra, Rouphael Nadine, Higuita Nelson Iván Agudelo, Atkinson Mark A, Brakenridge Scott, Fung Monica, Messer William, IMPACC Network, Salehi-Rad Ramin, Altman Matthew C, Becker Patrice M, Bosinger Steven E, Eckalbar Walter, Hoch Annmarie, Doni Jayavelu Naresh, Kim-Schulze Seunghee, Jenkins Meagan, Kleinstein Steven H, Krammer Florian, Maecker Holden T, Ozonoff Al, Diray-Arce Joann, Shaw Albert, Baden Lindsey, Levy Ofer, Reed Elaine F, Langelier Charles R
Аннотация
Coronavirus disease 2019 (COVID-19) poses significant risks for solid organ transplant recipients, who have atypical but poorly characterized immune responses to infection. We aim to understand the host immunologic and microbial features of COVID-19 in transplant recipients by leveraging a prospective multicenter cohort of 86 transplant recipients age- and sex-matched with 172 non-transplant controls. We find that transplant recipients have higher nasal SARS-CoV-2 viral abundance and impaired viral clearance, and lower anti-spike IgG levels. In addition, transplant recipients exhibit decreased plasmablasts and transitional B cells, and increased senescent T cells. Blood and nasal transcriptional profiling demonstrate unexpected upregulation of innate immune signaling pathways and increased levels of several proinflammatory serum chemokines. Severe disease in transplant recipients, however, is characterized by a less robust induction of pro-inflammatory genes and chemokines. Together, our study reveals distinct immune features and altered viral dynamics in solid organ transplant recipients.