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DOI 10.1016/j.xgen.2024.100692

Медицинская библиотека · Cell genomics · 2024

Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas.

Borda Victor, Loesch Douglas P, Guo Bing, Laboulaye Roland, Veliz-Otani Diego, French Jennifer N, Leal Thiago Peixoto, Gogarten Stephanie M, Ikpe Sunday, Gouveia Mateus H, Mendes Marla, Abecasis Gonçalo R, Alvim Isabela, Arboleda-Bustos Carlos E, Arboleda Gonzalo, Arboleda Humberto, Barreto Mauricio L, Barwick Lucas, Bezzera Marcos A, Blangero John, Borges Vanderci, Caceres Omar, Cai Jianwen, Chana-Cuevas Pedro, Chen Zhanghua, Custer Brian, Dean Michael, Dinardo Carla, Domingos Igor, Duggirala Ravindranath, Dieguez Elena, Fernandez Willian, Ferraz Henrique B, Gilliland Frank, Guio Heinner, Horta Bernardo, Curran Joanne E, Johnsen Jill M, Kaplan Robert C, Kelly Shannon, Kenny Eimear E, Konkle Barbara A, Kooperberg Charles, Lescano Andres, Lima-Costa M Fernanda, Loos Ruth J F, Manichaikul Ani, Meyers Deborah A, Naslavsky Michel S, Nickerson Deborah A, North Kari E, Padilla Carlos, Preuss Michael, Raggio Victor, Reiner Alexander P, Rich Stephen S, Rieder Carlos R, Rienstra Michiel, Rotter Jerome I, Rundek Tatjana, Sacco Ralph L, Sanchez Cesar, Sankaran Vijay G, Santos-Lobato Bruno Lopes, Schumacher-Schuh Artur Francisco, Scliar Marilia O, Silverman Edwin K, Sofer Tamar, Lasky-Su Jessica, Tumas Vitor, Weiss Scott T, Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD), National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN) Consortium, Trans-Omics for Precision Medicine (TOPMed) Population Genetics Working Group, Mata Ignacio F, Hernandez Ryan D, Tarazona-Santos Eduardo, O'Connor Timothy D

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Аннотация

Latin Americans are underrepresented in genetic studies, increasing disparities in personalized genomic medicine. Despite available genetic data from thousands of Latin Americans, accessing and navigating the bureaucratic hurdles for consent or access remains challenging. To address this, we introduce the Genetics of Latin American Diversity (GLAD) Project, compiling genome-wide information from 53,738 Latin Americans across 39 studies representing 46 geographical regions. Through GLAD, we identified heterogeneous ancestry composition and recent gene flow across the Americas. Additionally, we developed GLAD-match, a simulated annealing-based algorithm, to match the genetic background of external samples to our database, sharing summary statistics (i.e., allele and haplotype frequencies) without transferring individual-level genotypes. Finally, we demonstrate the potential of GLAD as a critical resource for evaluating statistical genetic software in the presence of admixture. By providing this resource, we promote genomic research in Latin Americans and contribute to the promises of personalized medicine to more people.

Для цитирования: Borda Victor, Loesch Douglas P, Guo Bing, Laboulaye Roland, Veliz-Otani Diego, French Jennifer N, Leal Thiago Peixoto, Gogarten Stephanie M, Ikpe Sunday, Gouveia Mateus H, Mendes Marla, Abecasis Gonçalo R, Alvim Isabela, Arboleda-Bustos Carlos E, Arboleda Gonzalo, Arboleda Humberto, Barreto Mauricio L, Barwick Lucas, Bezzera Marcos A, Blangero John, Borges Vanderci, Caceres Omar, Cai Jianwen, Chana-Cuevas Pedro, Chen Zhanghua, Custer Brian, Dean Michael, Dinardo Carla, Domingos Igor, Duggirala Ravindranath, Dieguez Elena, Fernandez Willian, Ferraz Henrique B, Gilliland Frank, Guio Heinner, Horta Bernardo, Curran Joanne E, Johnsen Jill M, Kaplan Robert C, Kelly Shannon, Kenny Eimear E, Konkle Barbara A, Kooperberg Charles, Lescano Andres, Lima-Costa M Fernanda, Loos Ruth J F, Manichaikul Ani, Meyers Deborah A, Naslavsky Michel S, Nickerson Deborah A, North Kari E, Padilla Carlos, Preuss Michael, Raggio Victor, Reiner Alexander P, Rich Stephen S, Rieder Carlos R, Rienstra Michiel, Rotter Jerome I, Rundek Tatjana, Sacco Ralph L, Sanchez Cesar, Sankaran Vijay G, Santos-Lobato Bruno Lopes, Schumacher-Schuh Artur Francisco, Scliar Marilia O, Silverman Edwin K, Sofer Tamar, Lasky-Su Jessica, Tumas Vitor, Weiss Scott T, Latin American Research Consortium on the Genetics of Parkinson’s Disease (LARGE-PD), National Institute of Neurological Disorders and Stroke (NINDS) Stroke Genetics Network (SiGN) Consortium, Trans-Omics for Precision Medicine (TOPMed) Population Genetics Working Group, Mata Ignacio F, Hernandez Ryan D, Tarazona-Santos Eduardo, O'Connor Timothy D. Genetics of Latin American Diversity Project: Insights into population genetics and association studies in admixed groups in the Americas.. Cell genomics. 2024. DOI: 10.1016/j.xgen.2024.100692.

Предметные рубрики MeSH

HumansLatin AmericaGenetics, PopulationGenome-Wide Association StudyHaplotypesAlgorithmsGenetic VariationSoftware
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