Intense leuco-erythroblastic blood picture resembling erythro-leukaemia in sickle cell disease: a case report.

Florid leuco-erythroblastic blood picture in sickle cell disease (SCD) resembling chronic myeloid leukaemia and secondary dyserythropoietic activity resembling Di Guglielmo's disease in SCD have previously been reported. The aim of this study is to further focus attention on this phenomenon and to report that megaloblastic crisis in SCD can be misdiagnosed as acute leukaemia (erythroleukaemia). The need to do haemoglobin electrophoresis in all suspected cases of acute or chronic leukaemia in people of African ancestry is advocated.