Chemotherapy Sparks Tertiary Lymphoid Structures in Metastatic Ovarian Cancer.

Ovarian cancer remains resistant to immunotherapy in most patients, highlighting the need to make these tumors more immunogenic. A recent study unveils how chemotherapy is able to induce cancer cell stress in metastatic ovarian carcinomas, inducing the formation of tertiary lymphoid structures that create a "hotter" tumor microenvironment. See related article by Lanickova et al., p. 164.