Annals of medicine · 2025
Association between neutrophil-to-lymphocyte ratio and early renal function decline in patients with immunoglobulin a nephropathy.
СтатьяНаблюдательное исследованиеПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Shen Cun, Liu Mengchao, Cai Zhen, Wang Mengdi, Tian Lei, Tang Long, Cui Fangqiang, Zhao Wenjing
Аннотация
BACKGROUND: IgA nephropathy (IgAN) is a chronic immune-mediated progressive kidney disease. The Neutrophil-To-Lymphocyte Ratio (NLR) has emerged as a novel marker for systemic immune inflammation. This study aimed to explore the relationship between NLR and early renal function decline in patients with IgAN.
METHODS: A real-world cross-sectional observational study was conducted on a cohort of 1073 patients diagnosed with IgAN. Patients were stratified into high and low NLR groups based on a predefined cut-off value. We examined the association between NLR levels and reduced renal function across these groups, defined as an estimated glomerular filtration rate (eGFR) of 60 mL/min·1.73 m2 or less, using receiver operating characteristic (ROC) curve analysis and Logistic regression models.
RESULTS: Among the 1,073 patients evaluated, those with an eGFR ≤ 60 mL/min·1.73 m2 had significantly higher NLR levels compared to those with eGFR > 60 mL/min·1.73 m2 (Z = 9.598, p < 0.001). The area under the AUROC for NLR was 0.671 (p = 0.000, 95% CI: 0.638-0.703). The high NLR group showed significantly elevated levels of mean arterial pressure, 24-hour urinary protein and uric acid, along with lower hemoglobin, serum albumin, and eGFR (all p < 0.001). Multivariate logistic regression analysis revealed that high NLR was independently associated with reduced eGFR (≤ 60 mL/min·1.73 m2) (p = 0.009, OR = 2.110, 95% CI: 1.208-3.683). A nomogram was developed to identify IgAN patients with reduced eGFR (≤60 mL/min·1.73 m2).
CONCLUSIONS: IgAN patients with higher NLR levels exhibited more severe clinical manifestations. A high NLR may be associated with an increased risk of eGFR ≤ 60 mL/min·1.73 m2 in patients with IgAN.
METHODS: A real-world cross-sectional observational study was conducted on a cohort of 1073 patients diagnosed with IgAN. Patients were stratified into high and low NLR groups based on a predefined cut-off value. We examined the association between NLR levels and reduced renal function across these groups, defined as an estimated glomerular filtration rate (eGFR) of 60 mL/min·1.73 m2 or less, using receiver operating characteristic (ROC) curve analysis and Logistic regression models.
RESULTS: Among the 1,073 patients evaluated, those with an eGFR ≤ 60 mL/min·1.73 m2 had significantly higher NLR levels compared to those with eGFR > 60 mL/min·1.73 m2 (Z = 9.598, p < 0.001). The area under the AUROC for NLR was 0.671 (p = 0.000, 95% CI: 0.638-0.703). The high NLR group showed significantly elevated levels of mean arterial pressure, 24-hour urinary protein and uric acid, along with lower hemoglobin, serum albumin, and eGFR (all p < 0.001). Multivariate logistic regression analysis revealed that high NLR was independently associated with reduced eGFR (≤ 60 mL/min·1.73 m2) (p = 0.009, OR = 2.110, 95% CI: 1.208-3.683). A nomogram was developed to identify IgAN patients with reduced eGFR (≤60 mL/min·1.73 m2).
CONCLUSIONS: IgAN patients with higher NLR levels exhibited more severe clinical manifestations. A high NLR may be associated with an increased risk of eGFR ≤ 60 mL/min·1.73 m2 in patients with IgAN.