Controversies and Opportunities of a Nonbiopsy Diagnosis for Celiac Disease.

In this article, we will examine the role of biopsy in the diagnosis of celiac disease. We will cover the historical place biopsy has held, current practice for diagnosing celiac disease, advancement of serology testing, controversy of a nonbiopsy approach, and future considerations. The relative pitfalls and merits of biopsy and serology testing are covered.