The Egyptian journal of immunology · 2025
Detection of celiac disease in adult patients with type I diabetes mellitus.
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El-Kholy Nagla M B, El-Gendy Naglaa A, Mohammed Nessren M B, Abd El Hamid Hala E, Hassan Asmaa S, Mohamed Ayatalla R
Аннотация
Celiac disease (CD) is a chronic, immune-determined disorder that affects the small intestine in individuals with a genetic predisposition. Identifying silent CD is crucial, as a gluten-free diet in asymptomatic type 1 diabetes mellitus (T1DM) patients can improve glycemic control and growth. This study aimed to determine the prevalence of CD in adult T1DM patients by using serological immune-enzymatic tests. The study included 90 patients divided into two groups: Group 1 included 45 adults with T1DM (aged 20-40 years) exhibiting gastrointestinal symptoms of CD. Group 2 consisted of 45 asymptomatic adults with T1DM (aged 20-40 years). Celiac serology markers were positive in 3 patients (6.7%) from Group 1 and in 1 patient (2.2%) from Group 2. In Conclusion, there is a significant association between CD and T1DM. Celiac serology should be conducted in T1DM patients presenting with gastrointestinal and/or extraintestinal symptoms.