The Consortium for Clarity in ADRD Research Through Imaging (CLARiTI): Overview of consortium sites and anticipated enrollment.
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Oomens Julie E, Biber Sarah A, Albert Marilyn, Alosco Michael L, Arfanakis Konstantinos, Benzinger Tammie L S, Brewer James B, Burns Jeffrey M, Chin Erin, Chin Nathaniel A, Clark Lindsay R, Cohen Ann D, Dage Jeffrey L, Detre John A, Dickerson Bradford C, DiFilippo Frank P, Donohue Michael C, van Dyck Christopher H, Fan Audrey P, Grabowski Thomas J, Habes Mohamad, Harrison Theresa M, Hedden Trey, Hohman Timothy J, Jagust William J, Jefferson Angela L, Jicha Gregory A, Kecskemeti Steven R, Kantarci Kejal, Keene Dirk C, Knoefel Janice E, Kukull Walter A, Lin Weili, Lao Patrick, Lepping Rebecca J, Levendovszky Swati R, Masurkar Arjun V, McConathy Jonathan E, Rivera-Mindt Monica, Morhardt Darby J, Noll Douglas C, Okonkwo Ozioma C, Parrish Todd B, Rabinovici Gil D, Rahman-Filipiak Annalise, Reiman Eric M, Risacher Shannon L, Rosen Howie, Rudolph Marc D, Schneider Lon S, Silbert Lisa C, Song Allen W, Stark Craig E L, Swerdlow Russel H, Thompson Paul M, Vaillancourt David, Villemagne Victor L, Wolk David A, Qiu Deqiang, Foroud Tatiana M, Johnson Sterling C, Mormino Elizabeth C
Аннотация
METHODS: We developed and distributed a survey capturing information on the 36 CLARiTI site's theme/expertise, recruitment plans, and the intersection of CLARiTI with other ADRC imaging efforts.
RESULTS: Anticipated CLARiTI enrollees spanned 11 different categories of suspected etiologies underlying impairment. A wide range of risk factors were endorsed across sites regarding the enrollment of unimpaired individuals. Variability also existed regarding site-level strategies in enrollment into CLARiTI versus other imaging efforts.
DISCUSSION: We anticipate that the 2000 individuals that will enroll into CLARiTI will reflect the clinical heterogeneity already in place across the ADRC network.
HIGHLIGHTS: The ADRC Consortium for Clarity in ADRD Research Through Imaging (CLARiTI) will leverage and contribute to the existing Alzheimer's Disease Research Centers (ADRC) program by supporting standardized imaging and plasma collection across all centers. We summarize the variation in scientific focus and enrollment plans across ADRC sites participating in CLARiTI. The anticipated CLARiTI cohort will reflect the clinical heterogeneity that already exists across the ADRC network. CLARiTI will contribute to scientific goals related to the detection of multi-etiological signatures relevant for Alzheimer's disease and related disorders (ADRDs).