[Clinical study of the effect of amnion membrane transplantation on diminishing corneal neovascularization induced by alkali burn].

PURPOSE: To study the curative effect of amnion membrane transplantation on decreasing corneal neovascularization(CNV) induced by alkali burn.

METHODS

It was a non-randomized retrospective case-control study. Among 19 cases (23 eyes) of third-degree alkali burns from 2006 to 2010, 11 cases (13 eyes) were performed with amnion membrane transplantation operation, and others were not. Amnion membrane transplantation was performed at 3rd day after burns in the treatment group. Ages and treatments beyond surgery of double groups were matched. Areas of CNV in double groups were measured at the 14th and 60th days after burn. RESULTS：Area of CNV in the treatment group was (62.133±8.571) mm² at the 14th day after burn, and was 30.6% lower than that in the control group. Area of CNV in the treatment group was (112.019±17.362)mm² at the 14th day after burn, and was 13.5% lower than that in the control group. There was statistical significance between the two groups (P<0.05).

CONCLUSION

Amnion membrane transplantation operation can inhibit the growth of corneal neovascularization induced by alkali burn.