Morphological analysis of newly formed vessels and cellular microenvironment.

Newly formed microvessels were studied by the topical method (combination of light and electron microscopy with preliminary visualization of the isolated new vessel with horseradish peroxidase) on day 8 of growth. Five different zones with different transport characteristics of the vascular wall and cellular microenvironment were detected over the vascular length. A direct correlation between cellular microenvironment and formation of transporting canals in the endothelial lining of the newly formed vessels was detected.