Scientific reports · 2024
The comparison of pathogenicity among SARS-CoV-2 variants in domestic cats.
СтатьяСравнительное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Park Eun-Sil, Kuroda Yudai, Uda Akihiko, Kaku Yoshihiro, Okutani Akiko, Hotta Akitoyo, Tatemoto Kango, Ishijima Keita, Inoue Yusuke, Harada Michiko, Ami Yasushi, Shirakura Masayuki, Watanabe Shinji, Suzuki Yasushi, Harada Toshihiko, Ainai Akira, Shiwa Nozomi, Sakai Yusuke, Iwata-Yoshikawa Naoko, Nagata Noriyo, Suzuki Tadaki, Hasegawa Hideki, Maeda Ken
Аннотация
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been detected or isolated from domestic cats. It is unclear whether cats play an important role in the SARS-CoV-2 transmission cycle. In this study, we examined the susceptibility of cats to SARS-CoV-2, including wild type and variants, by animal experiments. Cats inoculated with wild type, gamma, and delta variants secreted a large amount of SARS-CoV-2 for 1 week after the inoculation from nasal, oropharyngeal, and rectal routes. Only 100 TCID50 of virus could infect cats and replicate well without severe clinical symptoms. In addition, one cat inoculated with wild type showed persistent virus secretion in feces for over 28 days post-inoculation (dpi). The titer of virus-neutralizing (VN) antibodies against SARS-CoV-2 increased from 11 dpi, reaching a peak at 14 dpi. However, the omicron variant could not replicate well in cat tissues and induced a lower titer of VN antibodies. It is concluded that cats were highly susceptible to SARS-CoV-2 infection, but not to the Omicron Variant, which caused the attenuated pathogenicity.