Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2026
A discrepancy in epiretinal proliferation detection between preoperative OCT and intraoperative observation in macular hole.
СтатьяНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…
Ошибки и ограничения
История · было → стало
Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.
Fukushima Masaki, Hayashi Atsushi, Kusaka Shunji, Kamei Motohiro, Akai Ryota, Tsuboi Kotaro
Аннотация
PURPOSE: Epiretinal proliferation (EP) is associated with poor visual and anatomical outcomes in eyes with macular holes (MHs). A preoperative cross-sectional OCT can detect EP; however, We observed that some cases with intraoperatively visible EP showed no evidence of EP on preoperative OCT. This study assessed the discrepancy between EP observed by OCT and during surgery.
METHODS: We defined OCT-EP as epiretinal materials with homogeneous medium reflectivity observed in cross-sectional OCT. We defined surgical-EP as yellowish tissues contiguous to the hole during the membrane peeling. We detected the surgical-EP by also assessing the internal limiting membrane staining pattern using Brilliant Blue G (BBG) and preretinal abnormal tissue (PAT) using en face OCT.
RESULTS: We included 110 eyes. Intraoperative observations revealed surgical-EP in 30 (27%) eyes, while preoperative OCT revealed EP in 26 (24%) eyes. Setting the surgical-EP as the ground truth gave a sensitivity of preoperative OCT for the detection of EP of 87% and specificity of 100%. In 4 of the 30 eyes (13%), EP was not detected on preoperative OCT and all of these eyes exhibited peri-MH nonstaining areas. Peri-MH nonstaining area and peri-MH PAT were larger in eyes with surgical-EP than in eyes without surgical-EP (P = 0.0001 and P = 0.0029).The area under the receiver operating characteristic curve was 84.3% for the peri-MH nonstaining area for detection of surgical-EP and 94.8% for peri-MH PAT.
CONCLUSIONS: Preoperative cross-sectional OCT may overlook EP. The BBG staining patterns and en face OCT provide additional clues for detecting EP. Key messages What is known • Epiretinal proliferation (EP) is a known biomarker correlated with poor visual and anatomical outcomes in eyes with macular hole. • Cross-sectional OCT is the standard modality for the detection of preoperative EP but may fail to identify subtle cases. What is new • There is a 13% discrepancy between preoperative OCT and intraoperative observation to detect EP. • Using only preoperative cross-sectional OCT may overlook the presence of EP. • Brilliant blue G staining pattern and en face OCT may be useful to identify undetectable EP by OCT.
METHODS: We defined OCT-EP as epiretinal materials with homogeneous medium reflectivity observed in cross-sectional OCT. We defined surgical-EP as yellowish tissues contiguous to the hole during the membrane peeling. We detected the surgical-EP by also assessing the internal limiting membrane staining pattern using Brilliant Blue G (BBG) and preretinal abnormal tissue (PAT) using en face OCT.
RESULTS: We included 110 eyes. Intraoperative observations revealed surgical-EP in 30 (27%) eyes, while preoperative OCT revealed EP in 26 (24%) eyes. Setting the surgical-EP as the ground truth gave a sensitivity of preoperative OCT for the detection of EP of 87% and specificity of 100%. In 4 of the 30 eyes (13%), EP was not detected on preoperative OCT and all of these eyes exhibited peri-MH nonstaining areas. Peri-MH nonstaining area and peri-MH PAT were larger in eyes with surgical-EP than in eyes without surgical-EP (P = 0.0001 and P = 0.0029).The area under the receiver operating characteristic curve was 84.3% for the peri-MH nonstaining area for detection of surgical-EP and 94.8% for peri-MH PAT.
CONCLUSIONS: Preoperative cross-sectional OCT may overlook EP. The BBG staining patterns and en face OCT provide additional clues for detecting EP. Key messages What is known • Epiretinal proliferation (EP) is a known biomarker correlated with poor visual and anatomical outcomes in eyes with macular hole. • Cross-sectional OCT is the standard modality for the detection of preoperative EP but may fail to identify subtle cases. What is new • There is a 13% discrepancy between preoperative OCT and intraoperative observation to detect EP. • Using only preoperative cross-sectional OCT may overlook the presence of EP. • Brilliant blue G staining pattern and en face OCT may be useful to identify undetectable EP by OCT.