[Comparison and improvement in the methods of establishing animals model of experimental chronic sinusitis in rabbits].

OBJECTIVE

To compare and improve the methods of establishing animal model of experimental chronic sinusitis in rabbits .

METHODS

Sixty-six New Zealand white rabbits were divided into seven groups: control group, sham-operation group I, sham-operation group II, bacteria inoculation group, ostia-blocked group, ostia-blocked and bacteria inoculation group, incomplete ostium blocked and set-cotton group. The animals were examined by the methods of histology and bacteriology after 42 days.

RESULTS

The positive rate of chronic inflammation in ostium blocked group was 80%, inoculated staphylococcus group was 100%, incomplete ostium blocked and set-cotton group was 100%, and the other groups were 0%. All infected sinuses displayed signs of moderate or severe chronic inflammation. The cultivated bacteria were mainly opportunistic pathogens. The probability of having abscess in maxillary sinus was high in ostia-blocked and bacteria inoculation group.

CONCLUSIONS

The method of incomplete ostium blockage and set cotton can establish stable chronic sinusitis model, it is a simple and perfect method.