Journal of medical case reports · 2025
Dowling-Degos disease in a 23-year-old Jordanian male: a case report.
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Hanifa Hamdah, Hamdan Aya Mohannad, Baniamer Ansam Zakaria, Muhaidat Jihan Mohammed, Al-Sahoud Sultan Hussein, AlGhzawi Mohammad Raed, Alfaqeh Mohammad Tareq
Аннотация
BACKGROUND: Dowling-Degos disease is a rare genodermatosis disorder that presents as an autosomal dominant trait during late childhood or in adolescence and is also known as reticulate pigmented anomaly of flexures, Dowling-Degos-Kitamura, or dark dot disease. Dowling-Degos disease is characterized by acquired reticular hyperpigmentation, and manifests as a clustered or reticulated pattern mainly at flexural sites, especially in the folds of the skin with comedone-like follicular papules and pitted perioral scars. It appears in both genders but is more likely in females.
CASE PRESENTATION: A 23-year-old Jordanian male presented with progressive hyperpigmented macules and papules on his forehead, initially managed with Triderma cream without improvement. Histopathological examination via punch biopsies revealed features consistent with Dowling-Degos disease, excluding malignancy. Treatment was transitioned to sunblock, depigmenting agents (Isis Unit One 4 White), and moisturizers, resulting in significant fading of lesions after 8 months. Genetic counseling was provided owing to the hereditary nature of Dowling-Degos disease, and long-term management strategies were emphasized.
CONCLUSION: Dowling-Degos disease is a rare genodermatosis that can cause significant psychological distress and a decline in quality of life. Despite challenging treatment, a multidisciplinary approach is essential for improving patient outcomes and managing the elevated risk of skin cancers.
CASE PRESENTATION: A 23-year-old Jordanian male presented with progressive hyperpigmented macules and papules on his forehead, initially managed with Triderma cream without improvement. Histopathological examination via punch biopsies revealed features consistent with Dowling-Degos disease, excluding malignancy. Treatment was transitioned to sunblock, depigmenting agents (Isis Unit One 4 White), and moisturizers, resulting in significant fading of lesions after 8 months. Genetic counseling was provided owing to the hereditary nature of Dowling-Degos disease, and long-term management strategies were emphasized.
CONCLUSION: Dowling-Degos disease is a rare genodermatosis that can cause significant psychological distress and a decline in quality of life. Despite challenging treatment, a multidisciplinary approach is essential for improving patient outcomes and managing the elevated risk of skin cancers.