The Modern Role of Radiation Therapy in Classic Hodgkin Lymphoma.

Radiation therapy (RT) has played a central role in the management of classic Hodgkin lymphoma (cHL) for over a century and remains an integral component of modern, risk-adapted treatment strategies. Advances in systemic therapy, molecular imaging, and radiation technique have enabled substantial reductions in treatment fields and dose while maintaining excellent disease control. This article reviews the evolution of RT in cHL, contemporary evidence guiding its use in early-stage and in advanced-stage disease, and its evolving role in relapsed and refractory settings, including peritransplant and emerging transplant-alternative approaches.