Malaria journal · 2025
Estimating the potential impact of surveillance test-and-treat posts to reduce malaria in border regions in sub-Saharan Africa: a modelling study.
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Topazian Hillary M, Charles Giovanni D, Schmit Nora, Pianella Matteo, Marshall John M, Kleinschmidt Immo, Hauck Katharina, Ghani Azra C
Аннотация
BACKGROUND: The last malaria cases in near-elimination settings are often found in international border regions due to the presence of hard-to-reach populations, conflict, uneven intervention coverage, and human migration. Test-and-treat border posts are an under-researched form of active case detection used to interrupt transmission chains between countries.
METHODS: An individual-based, mathematical metapopulation model of Plasmodium falciparum was used to estimate the effectiveness of border screening posts on total cases in malaria-endemic sub-Saharan Africa.
RESULTS: The implementation of international border posts across 401 sub-national administrative units would avert a median of 7173 (IQR 1075 to 23,550) cases per unit over a 10 year period and reduce PfPR2-10 by a median of 0.21% (IQR 0.04 to 0.44%).
CONCLUSIONS: Border posts were most effective in low-transmission settings with high-transmission neighbours. Border posts alone in sub-Saharan Africa will not allow a country to reach elimination, particularly when considering feasibility and acceptability, but could contribute to broader control packages to targeted populations.
METHODS: An individual-based, mathematical metapopulation model of Plasmodium falciparum was used to estimate the effectiveness of border screening posts on total cases in malaria-endemic sub-Saharan Africa.
RESULTS: The implementation of international border posts across 401 sub-national administrative units would avert a median of 7173 (IQR 1075 to 23,550) cases per unit over a 10 year period and reduce PfPR2-10 by a median of 0.21% (IQR 0.04 to 0.44%).
CONCLUSIONS: Border posts were most effective in low-transmission settings with high-transmission neighbours. Border posts alone in sub-Saharan Africa will not allow a country to reach elimination, particularly when considering feasibility and acceptability, but could contribute to broader control packages to targeted populations.