Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons · 2025
Does 810-nm Diode Laser Photobiomodulation Improve Sensory Recovery After Le Fort I Surgery?
СтатьяРандомизированное исследованиеНазвание и аннотация: Перевод пока не подготовлен
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Ostadkhalil Fatemeh, Dehghani Nima, Yousefbeigi Ailar, Azarsina Mohadeseh, Hakimiha Neda
Аннотация
BACKGROUND: Neurosensory disturbances are common after Le Fort I osteotomy, often transient but clinically relevant, highlighting the need for strategies to enhance recovery. Photobiomodulation (PBM) using low-level diode lasers has been proposed to accelerate nerve recovery.
PURPOSE: The purpose of study was to compare midface sensory recovery and subject satisfaction between PBM with an 810-nm diode laser and a control side (inactive probe) following Le Fort I osteotomy.
STUDY DESIGN, SETTING, SAMPLE: A prospective triple-blind, split-face randomized controlled trial was conducted from 2021 to 2022 at 2 tertiary hospitals in Tehran. Eligible participants aged 18-40 years who underwent bimaxillary surgery with Le Fort I osteotomy. Exclusion criteria included trauma history, oral diseases, uncontrolled systemic diseases, and contraindications to laser therapy.
PREDICTOR VARIABLE: The predictor variable was the PBM treatment (810-nm GaAlAs diode laser). Treatments were randomly assigned to 1 side of the midface (PBM) while the contralateral side served as the control (inactive probe).
MAIN OUTCOME VARIABLE(S): The primary outcome variable was time to functional sensory recovery (FSR), defined as Medical Research Council Scale S3+. It was measured using a composite of standardized neurosensory tests (2-point discrimination, brush stroke directional, and thermal and sharp/blunt discrimination). Secondary outcomes included subject satisfaction, measured with a 10-point visual analog scale.
COVARIATES: Covariates included age, sex, and time since surgery.
ANALYSES: Descriptive statistics, Kaplan-Meier survival analysis, repeated-measures analysis of variance, and Mann-Whitney U tests were used. Statistical significance was set at P < .05.
RESULTS: The study included 15 subjects (mean age 29.3 ± 7.0 years), with a 35-day follow-up. Median time to FSR was 28 days (interquartile range: 24-32) for the upper lip and 35 days (interquartile range: 30-40) for the nasolabial fold, with no statistically significant differences between PBM and control sides (Log-rank P > .05). Sensory function improved statistically significantly over time, but recovery trajectories did not differ between sides. Subject satisfaction was similar between groups.
CONCLUSION AND RELEVANCE: Postoperative PBM at 810 nm did not statistically significantly accelerate FSR compared to the control side. However, it was safe and associated with improved subject satisfaction at the final follow-up, suggesting a potential role in enhancing the subjective postoperative experience.
PURPOSE: The purpose of study was to compare midface sensory recovery and subject satisfaction between PBM with an 810-nm diode laser and a control side (inactive probe) following Le Fort I osteotomy.
STUDY DESIGN, SETTING, SAMPLE: A prospective triple-blind, split-face randomized controlled trial was conducted from 2021 to 2022 at 2 tertiary hospitals in Tehran. Eligible participants aged 18-40 years who underwent bimaxillary surgery with Le Fort I osteotomy. Exclusion criteria included trauma history, oral diseases, uncontrolled systemic diseases, and contraindications to laser therapy.
PREDICTOR VARIABLE: The predictor variable was the PBM treatment (810-nm GaAlAs diode laser). Treatments were randomly assigned to 1 side of the midface (PBM) while the contralateral side served as the control (inactive probe).
MAIN OUTCOME VARIABLE(S): The primary outcome variable was time to functional sensory recovery (FSR), defined as Medical Research Council Scale S3+. It was measured using a composite of standardized neurosensory tests (2-point discrimination, brush stroke directional, and thermal and sharp/blunt discrimination). Secondary outcomes included subject satisfaction, measured with a 10-point visual analog scale.
COVARIATES: Covariates included age, sex, and time since surgery.
ANALYSES: Descriptive statistics, Kaplan-Meier survival analysis, repeated-measures analysis of variance, and Mann-Whitney U tests were used. Statistical significance was set at P < .05.
RESULTS: The study included 15 subjects (mean age 29.3 ± 7.0 years), with a 35-day follow-up. Median time to FSR was 28 days (interquartile range: 24-32) for the upper lip and 35 days (interquartile range: 30-40) for the nasolabial fold, with no statistically significant differences between PBM and control sides (Log-rank P > .05). Sensory function improved statistically significantly over time, but recovery trajectories did not differ between sides. Subject satisfaction was similar between groups.
CONCLUSION AND RELEVANCE: Postoperative PBM at 810 nm did not statistically significantly accelerate FSR compared to the control side. However, it was safe and associated with improved subject satisfaction at the final follow-up, suggesting a potential role in enhancing the subjective postoperative experience.