Cancer reports (Hoboken, N.J.) · 2024
Plasma Profiling of Acute Myeloid Leukemia With Fever- and Infection-Related Complications During Chemotherapy-Induced Neutropenia.
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Kreft Iris C, van de Geer Annemarie, Smit Eva R, van der Zwaan Carmen, van Alphen Floris P J, Meijer Alexander B, Nur Erfan, Hoogendijk Arie J, Kuijpers Taco W, van den Biggelaar Maartje
Аннотация
BACKGROUND: Acute myeloid leukemia (AML) is a heterogenous and complex blood cancer requiring aggressive treatment. Early identification and prediction of the complications following treatment is vital for effective disease management.
AIMS: We explored associations between plasma protein levels and fever- and infection-related complications in 26 AML patients during chemotherapy-induced neutropenia.
MATERIAL AND METHODS: Longitudinal plasma profiling was conducted using data-dependent mass spectrometry analysis.
RESULTS: Mass spectrometry-based plasma profiling data correlated well with laboratory parameters, including C-reactive protein, and revealed a broader inflammation protein network associated with fever- and infection-related complications.
DISCUSSION AND CONCLUSION: These data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.
AIMS: We explored associations between plasma protein levels and fever- and infection-related complications in 26 AML patients during chemotherapy-induced neutropenia.
MATERIAL AND METHODS: Longitudinal plasma profiling was conducted using data-dependent mass spectrometry analysis.
RESULTS: Mass spectrometry-based plasma profiling data correlated well with laboratory parameters, including C-reactive protein, and revealed a broader inflammation protein network associated with fever- and infection-related complications.
DISCUSSION AND CONCLUSION: These data indicate the potential of longitudinal plasma profiling in AML patients for identifying and predicting complications that may aid in improved disease monitoring and treatment.