Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego · 2022
Is asthma with hypersenitivity to non-steroidal anti-inflammatory drugs is a risk factor for depression?
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Bąk Bartłomiej, Witusik Andrzej, Kamecki Krystian, Pietras Tadeusz
Аннотация
UNLABELLED: The respiratory tract disease exacerbated by non-steroidal antiinflammatory drugs (NSAIDs) is characterized by the Widal triad, which includes the presence of bronchial asthma, hypersensitivity to NSAIDs (acetylsalicylic acid) and chronic eosinophilic rhinitis and sinusitis (frequently also coincident with nasal polyps). Idiosyncratic hypersensitivity to NSAIDs in the course of bronchial asthma affects approximately 15% of patients.
AIM: The aim of the study is to assess depressiveness and severity of anxiety in the population of patients with partially and poorly controlled asthma.
MATERIALS AND METHODS: A group of 48 patients with partially and poorly controlled bronchial asthma without hypersensitivity to NSAIDs was selected, as well as 42 patients with partially and poorly controlled bronchial asthma hypersensitive to NSAIDs. All the patients underwent an asthma control test. To assess depression, the Beck Depression Scale - BDI II was used. When assessing anxiety as a trait and anxiety as a state, the Spielberger's STAI - State and Trait Anxiety Inventory - was used.
RESULTS: The mean age in the group with no hypersensitivity to NSAIDs was 51 +/- 15 years and did not differ with statistical significance from the group of patients hypersensitive to NSAIDs, where it was 50 +/- 14 years. The mean level of depression in the group without hypersensitivity was 15 +/- 9, and in the hypersensitivity group 23 +/- 8 and the difference reached the level of statistical significance p<0.005. Moreover, anxiety as a state was lower in the group without hypersensitivity compared to the group with hypersensitivity (the result expressed in sten scores: 6 +/- 2 versus 7 +/-2, p<0.001). Anxiety as a trait was 5 +/- 2 in both groups and there was no inter-group difference.
CONCLUSIONS: Subjects with partially and poorly controlled bronchial asthma and hypersensitivity to NSAIDs have a higher severity of depression and anxiety compared to those with partially and poorly controlled asthma without hypersensitivity to NSAIDs. In that group, anxiety as a state is also greater than in the group without hypersensitivity to NSAIDs.
AIM: The aim of the study is to assess depressiveness and severity of anxiety in the population of patients with partially and poorly controlled asthma.
MATERIALS AND METHODS: A group of 48 patients with partially and poorly controlled bronchial asthma without hypersensitivity to NSAIDs was selected, as well as 42 patients with partially and poorly controlled bronchial asthma hypersensitive to NSAIDs. All the patients underwent an asthma control test. To assess depression, the Beck Depression Scale - BDI II was used. When assessing anxiety as a trait and anxiety as a state, the Spielberger's STAI - State and Trait Anxiety Inventory - was used.
RESULTS: The mean age in the group with no hypersensitivity to NSAIDs was 51 +/- 15 years and did not differ with statistical significance from the group of patients hypersensitive to NSAIDs, where it was 50 +/- 14 years. The mean level of depression in the group without hypersensitivity was 15 +/- 9, and in the hypersensitivity group 23 +/- 8 and the difference reached the level of statistical significance p<0.005. Moreover, anxiety as a state was lower in the group without hypersensitivity compared to the group with hypersensitivity (the result expressed in sten scores: 6 +/- 2 versus 7 +/-2, p<0.001). Anxiety as a trait was 5 +/- 2 in both groups and there was no inter-group difference.
CONCLUSIONS: Subjects with partially and poorly controlled bronchial asthma and hypersensitivity to NSAIDs have a higher severity of depression and anxiety compared to those with partially and poorly controlled asthma without hypersensitivity to NSAIDs. In that group, anxiety as a state is also greater than in the group without hypersensitivity to NSAIDs.