JACC. Cardiovascular imaging · 2014
Quantification of myocardial blood flow in absolute terms using (82)Rb PET imaging: the RUBY-10 Study.
Сравнительное исследованиеСтатьяМногоцентровое исследованиеПоддержка NIH: внешняя программаПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Nesterov Sergey V, Deshayes Emmanuel, Sciagrà Roberto, Settimo Leonardo, Declerck Jerome M, Pan Xiao-Bo, Yoshinaga Keiichiro, Katoh Chietsugu, Slomka Piotr J, Germano Guido, Han Chunlei, Aalto Ville, Alessio Adam M, Ficaro Edward P, Lee Benjamin C, Nekolla Stephan G, Gwet Kilem L, deKemp Robert A, Klein Ran, Dickson John, Case James A, Bateman Timothy, Prior John O, Knuuti Juhani M
Аннотация
OBJECTIVES: The purpose of this study was to compare myocardial blood flow (MBF) and myocardial flow reserve (MFR) estimates from rubidium-82 positron emission tomography ((82)Rb PET) data using 10 software packages (SPs) based on 8 tracer kinetic models.
BACKGROUND: It is unknown how MBF and MFR values from existing SPs agree for (82)Rb PET.
METHODS: Rest and stress (82)Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs.
RESULTS: The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM.
CONCLUSIONS: SPs using the most common kinetic model-OHI-1-TCM-provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol.
BACKGROUND: It is unknown how MBF and MFR values from existing SPs agree for (82)Rb PET.
METHODS: Rest and stress (82)Rb PET scans of 48 patients with suspected or known coronary artery disease were analyzed in 10 centers. Each center used 1 of 10 SPs to analyze global and regional MBF using the different kinetic models implemented. Values were considered to agree if they simultaneously had an intraclass correlation coefficient >0.75 and a difference <20% of the median across all programs.
RESULTS: The most common model evaluated was the Ottawa Heart Institute 1-tissue compartment model (OHI-1-TCM). MBF values from 7 of 8 SPs implementing this model agreed best. Values from 2 other models (alternative 1-TCM and Axially distributed) also agreed well, with occasional differences. The MBF results from other models (e.g., 2-TCM and retention) were less in agreement with values from OHI-1-TCM.
CONCLUSIONS: SPs using the most common kinetic model-OHI-1-TCM-provided consistent results in measuring global and regional MBF values, suggesting that they may be used interchangeably to process data acquired with a common imaging protocol.
Предметные рубрики MeSH
AdultAgedAged, 80 and overCoronary Artery DiseaseEuropeFemaleHemodynamicsHumansImage Interpretation, Computer-AssistedJapanMaleMiddle AgedModels, CardiovascularMyocardial Perfusion ImagingObserver VariationOntarioPositron-Emission TomographyPredictive Value of TestsRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesSoftwareUnited States