Mechanisms of malarial immunity.

Immunity to malaria in many species, including man, is acquired only after long exposure to infection and is associated with chronic low-grade parasitaemia. Vaccination of Rhesus monkeys with P. knowlesi merozoites in FCA induces sterilizing immunity which is species specific. Merozoite-blocking (inhibitory) antibody usually correlates with clinical immunity and protection can be passively transferred with immune sera. However, vaccination using adjuvants other than FCA may induce inhibitory antibody without clinical protection. In addition, vaccinated animals usually become susceptible to challenge 4 to 5 weeks after splenectomy, although inhibitory antibody levels are not reduced. These observations indicate that immunity induced by merozoite vaccination involves merozoite blocking (inhibitory) antibody and also specific antibody or immune complexes acting synergistically with cytotoxic splenic cells stimulated by FCA. During natural infection on the other hand soluble circulating antigens, partly derived from the merozoite coat during red cell penetration, are produced and these may block immune effector mechanisms and promote parasite survival.