m+Medelevator.RU
← Поиск публикаций
Nature · 2011

Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.

СтатьяПоддержка NIH: внешняя программаResearch Support, N.I.H., IntramuralПоддержка исследования: вне правительства СШАПоддержка правительства СШАПоддержка службы здравоохранения СШАНазвание и аннотация: Перевод пока не подготовлен
Обработка статьи · этапы, ошибки и управление
Загрузка состояния…

История · было → стало

Состояние обновляется каждые 5 секунд, пока блок открыт. Процент показывается только там, где известен объём работы. Пауза останавливает продолжение этапа; текущий запрос к источнику может завершиться.

International Consortium for Blood Pressure Genome-Wide Association Studies, Ehret Georg B, Munroe Patricia B, Rice Kenneth M, Bochud Murielle, Johnson Andrew D, Chasman Daniel I, Smith Albert V, Tobin Martin D, Verwoert Germaine C, Hwang Shih-Jen, Pihur Vasyl, Vollenweider Peter, O'Reilly Paul F, Amin Najaf, Bragg-Gresham Jennifer L, Teumer Alexander, Glazer Nicole L, Launer Lenore, Zhao Jing Hua, Aulchenko Yurii, Heath Simon, Sõber Siim, Parsa Afshin, Luan Jian'an, Arora Pankaj, Dehghan Abbas, Zhang Feng, Lucas Gavin, Hicks Andrew A, Jackson Anne U, Peden John F, Tanaka Toshiko, Wild Sarah H, Rudan Igor, Igl Wilmar, Milaneschi Yuri, Parker Alex N, Fava Cristiano, Chambers John C, Fox Ervin R, Kumari Meena, Go Min Jin, van der Harst Pim, Kao Wen Hong Linda, Sjögren Marketa, Vinay D G, Alexander Myriam, Tabara Yasuharu, Shaw-Hawkins Sue, Whincup Peter H, Liu Yongmei, Shi Gang, Kuusisto Johanna, Tayo Bamidele, Seielstad Mark, Sim Xueling, Nguyen Khanh-Dung Hoang, Lehtimäki Terho, Matullo Giuseppe, Wu Ying, Gaunt Tom R, Onland-Moret N Charlotte, Cooper Matthew N, Platou Carl G P, Org Elin, Hardy Rebecca, Dahgam Santosh, Palmen Jutta, Vitart Veronique, Braund Peter S, Kuznetsova Tatiana, Uiterwaal Cuno S P M, Adeyemo Adebowale, Palmas Walter, Campbell Harry, Ludwig Barbara, Tomaszewski Maciej, Tzoulaki Ioanna, Palmer Nicholette D, CARDIoGRAM consortium, CKDGen Consortium, KidneyGen Consortium, EchoGen consortium, CHARGE-HF consortium, Aspelund Thor, Garcia Melissa, Chang Yen-Pei C, O'Connell Jeffrey R, Steinle Nanette I, Grobbee Diederick E, Arking Dan E, Kardia Sharon L, Morrison Alanna C, Hernandez Dena, Najjar Samer, McArdle Wendy L, Hadley David, Brown Morris J, Connell John M, Hingorani Aroon D, Day Ian N M, Lawlor Debbie A, Beilby John P, Lawrence Robert W, Clarke Robert, Hopewell Jemma C, Ongen Halit, Dreisbach Albert W, Li Yali, Young J Hunter, Bis Joshua C, Kähönen Mika, Viikari Jorma, Adair Linda S, Lee Nanette R, Chen Ming-Huei, Olden Matthias, Pattaro Cristian, Bolton Judith A Hoffman, Köttgen Anna, Bergmann Sven, Mooser Vincent, Chaturvedi Nish, Frayling Timothy M, Islam Muhammad, Jafar Tazeen H, Erdmann Jeanette, Kulkarni Smita R, Bornstein Stefan R, Grässler Jürgen, Groop Leif, Voight Benjamin F, Kettunen Johannes, Howard Philip, Taylor Andrew, Guarrera Simonetta, Ricceri Fulvio, Emilsson Valur, Plump Andrew, Barroso Inês, Khaw Kay-Tee, Weder Alan B, Hunt Steven C, Sun Yan V, Bergman Richard N, Collins Francis S, Bonnycastle Lori L, Scott Laura J, Stringham Heather M, Peltonen Leena, Perola Markus, Vartiainen Erkki, Brand Stefan-Martin, Staessen Jan A, Wang Thomas J, Burton Paul R, Soler Artigas Maria, Dong Yanbin, Snieder Harold, Wang Xiaoling, Zhu Haidong, Lohman Kurt K, Rudock Megan E, Heckbert Susan R, Smith Nicholas L, Wiggins Kerri L, Doumatey Ayo, Shriner Daniel, Veldre Gudrun, Viigimaa Margus, Kinra Sanjay, Prabhakaran Dorairaj, Tripathy Vikal, Langefeld Carl D, Rosengren Annika, Thelle Dag S, Corsi Anna Maria, Singleton Andrew, Forrester Terrence, Hilton Gina, McKenzie Colin A, Salako Tunde, Iwai Naoharu, Kita Yoshikuni, Ogihara Toshio, Ohkubo Takayoshi, Okamura Tomonori, Ueshima Hirotsugu, Umemura Satoshi, Eyheramendy Susana, Meitinger Thomas, Wichmann H-Erich, Cho Yoon Shin, Kim Hyung-Lae, Lee Jong-Young, Scott James, Sehmi Joban S, Zhang Weihua, Hedblad Bo, Nilsson Peter, Smith George Davey, Wong Andrew, Narisu Narisu, Stančáková Alena, Raffel Leslie J, Yao Jie, Kathiresan Sekar, O'Donnell Christopher J, Schwartz Stephen M, Ikram M Arfan, Longstreth W T, Mosley Thomas H, Seshadri Sudha, Shrine Nick R G, Wain Louise V, Morken Mario A, Swift Amy J, Laitinen Jaana, Prokopenko Inga, Zitting Paavo, Cooper Jackie A, Humphries Steve E, Danesh John, Rasheed Asif, Goel Anuj, Hamsten Anders, Watkins Hugh, Bakker Stephan J L, van Gilst Wiek H, Janipalli Charles S, Mani K Radha, Yajnik Chittaranjan S, Hofman Albert, Mattace-Raso Francesco U S, Oostra Ben A, Demirkan Ayse, Isaacs Aaron, Rivadeneira Fernando, Lakatta Edward G, Orru Marco, Scuteri Angelo, Ala-Korpela Mika, Kangas Antti J, Lyytikäinen Leo-Pekka, Soininen Pasi, Tukiainen Taru, Würtz Peter, Ong Rick Twee-Hee, Dörr Marcus, Kroemer Heyo K, Völker Uwe, Völzke Henry, Galan Pilar, Hercberg Serge, Lathrop Mark, Zelenika Diana, Deloukas Panos, Mangino Massimo, Spector Tim D, Zhai Guangju, Meschia James F, Nalls Michael A, Sharma Pankaj, Terzic Janos, Kumar M V Kranthi, Denniff Matthew, Zukowska-Szczechowska Ewa, Wagenknecht Lynne E, Fowkes F Gerald R, Charchar Fadi J, Schwarz Peter E H, Hayward Caroline, Guo Xiuqing, Rotimi Charles, Bots Michiel L, Brand Eva, Samani Nilesh J, Polasek Ozren, Talmud Philippa J, Nyberg Fredrik, Kuh Diana, Laan Maris, Hveem Kristian, Palmer Lyle J, van der Schouw Yvonne T, Casas Juan P, Mohlke Karen L, Vineis Paolo, Raitakari Olli, Ganesh Santhi K, Wong Tien Y, Tai E Shyong, Cooper Richard S, Laakso Markku, Rao Dabeeru C, Harris Tamara B, Morris Richard W, Dominiczak Anna F, Kivimaki Mika, Marmot Michael G, Miki Tetsuro, Saleheen Danish, Chandak Giriraj R, Coresh Josef, Navis Gerjan, Salomaa Veikko, Han Bok-Ghee, Zhu Xiaofeng, Kooner Jaspal S, Melander Olle, Ridker Paul M, Bandinelli Stefania, Gyllensten Ulf B, Wright Alan F, Wilson James F, Ferrucci Luigi, Farrall Martin, Tuomilehto Jaakko, Pramstaller Peter P, Elosua Roberto, Soranzo Nicole, Sijbrands Eric J G, Altshuler David, Loos Ruth J F, Shuldiner Alan R, Gieger Christian, Meneton Pierre, Uitterlinden Andre G, Wareham Nicholas J, Gudnason Vilmundur, Rotter Jerome I, Rettig Rainer, Uda Manuela, Strachan David P, Witteman Jacqueline C M, Hartikainen Anna-Liisa, Beckmann Jacques S, Boerwinkle Eric, Vasan Ramachandran S, Boehnke Michael, Larson Martin G, Järvelin Marjo-Riitta, Psaty Bruce M, Abecasis Gonçalo R, Chakravarti Aravinda, Elliott Paul, van Duijn Cornelia M, Newton-Cheh Christopher, Levy Daniel, Caulfield Mark J, Johnson Toby

Аннотация

Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

Предметные рубрики MeSH

ИП Урсолов Владлен Сергеевич

ИНН 500118482352 · ОГРНИП 314500117700049

Реквизиты и контакты