Alzheimer's & dementia (Amsterdam, Netherlands) · 2026
Web-based LAS-FNAME and blood biomarkers in autosomal dominant Alzheimer's disease.
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Gonzalez Corona Christopher, Ospina Lopera Paula, Rowe Meredith C, Vila-Castelar Clara, Giudicessi Averi, Malotaux Vincent, He Bing, Tristão-Pereira Catarina, Martinez Jairo E, Osorio Asprilla Laura, Ramírez Gallego María Susana, Alzate Echeverri Diana Paola, Serna Laura, Ashton Nicholas J, Cuello A Claudio, Aguillon David, Quiroz Yakeel T
Аннотация
INTRODUCTION: This study examined whether performance on the web-based Latin American Spanish Face-Name Associative Memory Exam (LAS-FNAME), an associative memory test, is associated with plasma biomarkers in autosomal dominant Alzheimer's disease (ADAD).
METHODS: One hundred sixty-one members from the Colombian kindred with presenilin-1 (PSEN1) E280A mutation (61 cognitively unimpaired carriers, 22 cognitively impaired carriers, and 78 non-carriers), completed the web-based LAS-FNAME and provided blood samples for biomarker analysis. Analysis of covariance was used to compare LAS-FNAME performance among groups and Spearman correlations to examine its associations with levels of plasma phosphorylated tau (p-tau)217, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP).
RESULTS: Carriers had lower LAS-FNAME performance (P < 0.001) and higher p-tau217 (P < 0.001), NfL (P = 0.013), and GFAP (P < 0.001) levels than non-carriers. Higher p-tau217, NfL, and GFAP were associated with worse LAS-FNAME performance, controlling for age, sex, and education.
DISCUSSION: The web-based LAS-FNAME is a promising tool for detecting early memory decline in AD, warranting future studies to evaluate its longitudinal utility.
HIGHLIGHTS: The web-based Latin American Spanish Face-Name Associative Memory Exam (LAS-FNAME) detects memory decline in presenilin 1 (PSEN1) mutation carriers.LAS-FNAME scores correlate with blood biomarkers in PSEN1 carriers.The web-based format enables remote assessment via participants' personal devices.The study was conducted in Spanish-speaking adults at risk for dementia.Findings support combined use of digital cognitive tools and blood biomarkers.
METHODS: One hundred sixty-one members from the Colombian kindred with presenilin-1 (PSEN1) E280A mutation (61 cognitively unimpaired carriers, 22 cognitively impaired carriers, and 78 non-carriers), completed the web-based LAS-FNAME and provided blood samples for biomarker analysis. Analysis of covariance was used to compare LAS-FNAME performance among groups and Spearman correlations to examine its associations with levels of plasma phosphorylated tau (p-tau)217, neurofilament light chain (NfL), and glial fibrillary acidic protein (GFAP).
RESULTS: Carriers had lower LAS-FNAME performance (P < 0.001) and higher p-tau217 (P < 0.001), NfL (P = 0.013), and GFAP (P < 0.001) levels than non-carriers. Higher p-tau217, NfL, and GFAP were associated with worse LAS-FNAME performance, controlling for age, sex, and education.
DISCUSSION: The web-based LAS-FNAME is a promising tool for detecting early memory decline in AD, warranting future studies to evaluate its longitudinal utility.
HIGHLIGHTS: The web-based Latin American Spanish Face-Name Associative Memory Exam (LAS-FNAME) detects memory decline in presenilin 1 (PSEN1) mutation carriers.LAS-FNAME scores correlate with blood biomarkers in PSEN1 carriers.The web-based format enables remote assessment via participants' personal devices.The study was conducted in Spanish-speaking adults at risk for dementia.Findings support combined use of digital cognitive tools and blood biomarkers.