European neurology · 2006
The role of matrix metalloproteinase 9 in early neurological worsening of acute lacunar infarction.
СтатьяПоддержка исследования: вне правительства СШАНазвание и аннотация: Перевод пока не подготовлен
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Kim Young Seo, Lee Kyu-Yong, Koh Seong-Ho, Park Chang Yun, Kim Hyun Young, Lee Young Joo, Kim Hee Tae, Kim Juhan, Kim Myung-Ho, Kim Kyung Suk, Chang Dae-il, Kim Seung Hyun
Аннотация
The involvement of matrix metalloproteinases (MMPs) in ischemic-stroke-induced inflammatory response has recently been suggested; however, the relationship between MMPs and stroke progression has not been evaluated. We investigated the role of MMPs in neurological worsening of acute lacunar infarction. Forty-nine consecutive patients with an acute lacunar infarction (as defined by clinical and MRI criteria within 48 h after stroke onset) were evaluated. Clinical, biochemical, rheological, inflammatory and other parameters were compared between progressive and nonprogressive groups. Among the variables, only inflammatory parameters, including MMP-9 and erythrocyte sedimentation rate, were associated with neurological worsening of acute lacunar infarction (p<0.05). These results suggest that the inflammatory process could play an important role in early neurological worsening of acute lacunar infarction.