Acta neurologica Scandinavica · 2001
Abulia and cognitive impairment in two patients with capsular genu infarct.
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Pantoni L, Basile A M, Romanelli M, Piccini C, Sarti C, Nencini P, Inzitari D
Аннотация
BACKGROUND: An internal capsule genu infarct has been rarely reported to cause cognitive impairment and behavioral changes. This clinical picture can be explained on anatomical and functional basis because important subcortical-cortical pathways traverse the internal capsule genu. We report 2 previously non-demented patients who developed acute confusional state, abulia, and moderate cognitive decline after the occurrence of an infarct in the capsular genu.
METHODS: Clinical, neuropsychological, and MRI evaluation at baseline and 12-month follow-up.
RESULTS: Abulia and cognitive impairment were still present 1 year after stroke. In 1 patient there were associated multiple lacunar infarcts and leukoaraiosis. In the other an old small left frontal infarct was also present. In both moderate cortical atrophy co-existed.
CONCLUSIONS: We hypothesize that co-existing lesions, possibly associated with a sub-clinical reduction of cognitive functions, facilitate the development of a persistent clinically evident mental deficit after the occurrence of an infarct in the capsular genu.
METHODS: Clinical, neuropsychological, and MRI evaluation at baseline and 12-month follow-up.
RESULTS: Abulia and cognitive impairment were still present 1 year after stroke. In 1 patient there were associated multiple lacunar infarcts and leukoaraiosis. In the other an old small left frontal infarct was also present. In both moderate cortical atrophy co-existed.
CONCLUSIONS: We hypothesize that co-existing lesions, possibly associated with a sub-clinical reduction of cognitive functions, facilitate the development of a persistent clinically evident mental deficit after the occurrence of an infarct in the capsular genu.